微小病毒B19宫内感染与新生儿病理性黄疸的相关性研究

An association between human parvovirus B19 intrauterine infection and pathologic jaundice in newborn infants

目的观察人类微小病毒B19(HPV B19)宫内感染与新生儿病理性黄疸的关系。方法采用ELISA方法对 30例新生儿病理性黄疸进行了血清HPV B19-IgM及IgG的检测,并将48例正常新&Jb脐血作为对照组。结果 30例新生儿病理性黄疸中HPV B19-IgM阳性率为26．67％(8／30),48例正常对照组中HPV B19-IgM阳性率为4．17％(2／ 48)。与正常对照组比较,差异有非常显著性意义(x2=6．47 P<0．005相对危险度(RR)=6．4)。结论微小病毒B19 宫内感染与新生儿病理性黄疸相关。

Objective： To observe the relation of human parvovirus B19 （HPVB19） intrauterine infection with pathologic jaundice in newborn infants. Methods： The level of serum HPVB19 IgM was measured by ELISA in 30 pathologic jaundice in newborn infant and compared to that of 48 normal newborn infant. Results： The positive rate of serum HPVB19 IgM was 26.67% （8/30） in patholog- ic jaundice group, 4. 17% （2/48） in normal group, and significantly different in pathologic jaundice group （X^2 =6.47 and P 〈0. 005 and RR = 6.4）. Conclusion： HPVB19 intrauterine infection is related to the occurrence of pathologic jaundice in newborn infants.