期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

干扰素调节因子与Th细胞分化 被引量：4

下载PDF
导出
摘要 干扰素调节因子家族是公认的调节干扰素效应的转录因子。近年来研究发现,干扰素调节因子家族各成员之间以及与其它转录因子相互作用,通过调节抗原提呈细胞的功能以及直接作用于Th细胞本身,对Th向Th1或Th2分化起重要作用,可作为肿瘤或过敏性疾病治疗的一个靶点。
作者 马小兵 王海涛 畅继武
机构地区 天津医科大学第二医院天津市泌尿外科研究所肿瘤免疫研究室
出处 《现代免疫学》 CAS CSCD 北大核心 2006年第1期76-80,共5页 Current Immunology
关键词 干扰素调节因子 TH细胞 分化
分类号 R392.11 [医药卫生—免疫学]
  • 相关文献

参考文献20

  • 1Lohoff M, Mak TW. Roles of interferon-regulatory factors in T-helper-cell differentiation[J]. Nat Rev Immunol, 2005,5(2):125-135.
  • 2Liu J, Cao S, Herman LM, et al. Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-4gamma-primed IL-12 production by IFN regulatory factor 1[J]. J Exp Med, 2003,198(8):1265-1276.
  • 3Elser B, Lohoff M, Kock S, et al. 1FN-gamma represses IL-4 expression via IRF1 and IRF2[J]. Immunity,2002,17(6):703-712.
  • 4Niedbala W, Wei XQ, Campbell C, et al. Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor beta 2 expression via cGMP[J].Proe Natl Acad Sci USA, 2002,99(25):16186-16191.
  • 5Remoli ME, Giaeomini E, Lutfalla G, et al. Selective expression of type Ⅰ IFN genes in human dendritic cells infected with Mycobacterium tuberculosis[J]. J Immunol, 2002,169(1) :366-374.
  • 6Tominaga N, Ohkusu-Tsukada K, Udono H, et al. Development of Th1 and not Th2 immune responses in mice lacking IFN-regulatory factor-4 [J]. Int Immunol, 2003, 15(1): 1-10.
  • 7Hu CM, Jang SY, Fanzo JC, et al. Modulation of T cell cytoklne production by interferon regulatory factor-4 [J]. J Biol Chem, 2002,277(51) :49238-49246.
  • 8Lohoff M, Mittrucker HW, Brustle A, et al. Enhanced TCR induced apoptosis in interferon regulatory factor 4-deficient CD4(+) Th cells[J]. J Exp Med, 2004,200(2):247-253.
  • 9Rengarajan Hi, Mowen KA, McBride KD, et al. Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression[J]. J Exp Med,2002,195(8):1003-1012.
  • 10Lohoff M, Mittrucker HW, Preehtl S, et al. Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4[J]. Proc Natl Acad Sci USA, 2002,99(18):11808-11812.

二级参考文献19

  • 1[1]Mosmann TR, Cherwinski H, Bond MW, et al. Two types of murine helper T cell clone. Ⅰ. Definition according to profiles of lymphokine activities and secreted proteins[J]. J Immunol, 1986,136:2348
  • 2[2]Kaplan MH, Grusby MJ. Regulation of T helper cell differentiation by STAT molecules[J]. J Leukoc Biol, 1998,64:2
  • 3[3]Cua DJ, Stohlman SA. In vivo effects of T helper cell type 2 cytokines on macrophage antigen-presenting cell induction of T helper subsets [J]. J Immunol, 1997,159:5834
  • 4[4]Sallusto F,Lenig D,Mackay CR,et al. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes [J]. J Exp Med, 1998,187:875
  • 5[5]Sallusto F, Lanzavecchia A, Mackay GR. Chemokines and chemokine receptors in T-cell priming and Thl/Th2-mediated responses[J]. Immunol Today, 1998,19: 568
  • 6[6]Grakoui A,Donermeyer DL,Kanagawa O,et al. TCR-independent pathways mediate the effects of antigen dose and altered peptide ligands on Th cell polarization[J]. J Immunol, 1999,162:1923
  • 7[7]Del Prete GF,De Carli M,Mastromauro C,et al. Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen (s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper )profile of cytokine production[J]. J Clin Invest, 1991,88: 346
  • 8[8]Kapsenberg ML, Hilkens CM, Wierenga EA, et al. The role of antigenpresenting cells in the regulation of allergen-specific T cell responses[J]. Curr Opin Immunol,1998,10:607
  • 9[9]Kalinski P,Hilkens CM,Wierenga EA,et al. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal[J].Immunol Today, 1999,20:561
  • 10[10]Chambers CA Allison JP. Costimulatory regulation of T cell function[J]. Curr Opin Cell Biol, 1999,11:203

共引文献21

同被引文献50

  • 1陈海英,栗占国.干燥综合征动物模型的研究与应用现状[J].中华风湿病学杂志,2004,8(8):493-496. 被引量：16
  • 2韩瑞刚,彭瑞云,高亚兵,王瑞娟,付凯飞,马俊杰,陈建魁,胡文华,董波,王晓民.中子辐射后骨髓造血功能损伤以及IL-11受体的表达变化[J].中华放射医学与防护杂志,2006,26(2):133-136. 被引量：1
  • 3陈燚琼,陈建忠.IRF_7在干扰素诱导中作用的研究进展[J].国际流行病学传染病学杂志,2006,33(6):389-391. 被引量：1
  • 4Ohtsuka T, Jensen MR, Kim HG, et al. The negative role of cyclin G1 in ATM-dependent p53 activation. Oncogene, 2004, 23 (31) : 5405.
  • 5Maeda M, Ampo K, Kiryu-Seo S, et al. The p53-independent nuclear translocation of eyclin G1 in degenerating neurons by ischemic and traumatic insults. Exp Neurol, 2005, 193(2):350.
  • 6Seo HR, Lee DH, Lee HJ, et al. Cyclin G1 overcomes radiation-induced G2 arrest and increases cell death through transcriptional acti vation of cyclin B1. Cell Death Differ, 2006, 13(9):1475.
  • 7Hwang HC, Clurman BE. Cyclin E in normal and neoplastic cell cycles. Oncogene, 2005, 24(17):2776.
  • 8Loeb KR, Kostner H, Firpo E, et al. A mouse model for Cydin E dependent genetic instability and tumorigenesis. Cancer Cell, 2005, 8 (1) :35.
  • 9Payton M, Coats S. Cyclin E2, the cycle continues. Int J Biochem Cell Biol, 2002, 34(4):315.
  • 10Han J, Flemington C, Houghton A, et al. Expression of Bbc3, a pro-apoptotic BH3 only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci USA, 2001, 98(11): 318.

引证文献4

二级引证文献12

现代免疫学
2006年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部