活血化瘀治疗非瓣膜病性房颤血栓前状态的临床研究

Promoting Blood Circulation and Removing Stasis Therapy for the Pre-thrombus State in Non-valvular Heart Disease Patients with Atrial Fibrillation

目的探讨活血化瘀法对非瓣膜病性心房颤动(简称房颤)血栓前状态的治疗作用。方法将80例非瓣膜病性房颤血栓前状态的病人随机分成治疗组和对照组,治疗组服用血府逐瘀口服液,对照组服用肠溶阿司匹林片,分别观察治疗前后血瘀证的症状、体征、血液流变学、血栓5项[血小板α颗粒膜蛋白(GMP-140)、D-二聚体(D-D)、可溶性纤维蛋白单体复合物(SFMC)、组织纤溶酶原激活物(t-PA)、纤溶酶原激活物抑制物(PAI)];比较两组治疗前后血瘀证积分和血栓5项值的变化。结果治疗组治疗后血瘀证积分显著下降,与对照组比较有统计学意义;GMP-140和t-PA显著降低,与对照组比较有统计学意义;SFMC显著降低。结论血府逐瘀口服液对非瓣膜病性房颤血栓前状态有改善作用,在降低血瘀症积分和改善部分血栓前状态指标方面优于肠溶阿司匹林。

Objective To explore the effect of promoting blood circulation and removing stasis therapy on the pre - thrombus state in non - valvular heart disease patients （pts） with atrial fibrillation. Methods Eighty pts were divided into treatment group and control group. The pts in treatment group took Xuefuzhuyu Solution （XS）, pts in the control group took aspirin. The thrombus test （GMP 140, D - D, SFMC, t - PA, PAI） were tested. Results The blood stasis syndrome integrals in treatment group was reduced markedly than that in control group. GMP- 140 reduced in treatment group. There were no changes in D - D and PAI, Conclusion XS could improve the pre - thrombus state in non - valvular heart disease pts with atrial fibrillation.