多奈哌齐治疗血管性痴呆临床观察

Therapeutic Effect of Donepezil on Vascular Dementia

目的:观察多奈哌齐治疗血管性痴呆的疗效及安全性。方法:采用自身对照研究,36例血管性痴呆患者服用多奈哌齐治疗12周,治疗前及治疗后第4、12周各用简易智能精神状态检查量表(MMSE)和日常生活活动能力量表(ADL)评定疗效,并进行安全性评价。结果:多奈哌齐治疗12周后MMSE评分较治疗前提高3.6分,ADL评分较治疗前下降7.3分,差异均有显著性意义;3例(8.33%)出现轻度不良反应,均为一过性反应。结论:多奈哌齐治疗血管性痴呆有较好的疗效且安全性好。

Objective： To observe the efficacy and safety of donepezil in treatment of vascular dementia （VaD）. Methods： The selfmatched method was adopted. 36 patients with VaD wen give orally donepezil for 12 weeks. The efficacies wen assessed with MMSE ＆ ADL, and the safety after the treatment was also assessed.Results：The score of MMSE increased 3.6 points, while that of ADL decnased 7.3 points after treatment with donepezil for 12 weeks, the diffennees were significant. Then were 3 patients （8.33%） shewing mild side- effect which was temporary phenomenon. Conclusion： It is effective and safe to treat patients with VaD.