人胎盘催乳素测定对产前监护的价值

VALUE OF MEASURING THE HUMAN PLACENTAL LACTOGEN TO USE ANTEPARTUM MONITORING

１９９２年１２月～１９９４年１２月期间，为了进行产前监护，应用放射免疫分析方法，分析了晚期孕妇血清中的人胎盘催乳素（ＨＰＬ）。选择单次与末次测定距分娩时间小于或等于３天的正常孕妇１５６例，小于或等于２天的高危孕妇２５２例进行分析。结果：晚期孕妇（宫内孕３７～４２周）血清ＨＰＬ正常参考值为１１．９２±３．６ｍｇ／Ｌ（６．８～１６ｍｇ／Ｌ），并以ＨＰＬ＞６ｍｇ／Ｌ为正常值；４～６ｍｇ／Ｌ为可疑值；＜４ｍｇ／Ｌ为危险值。对ＨＰＬ值的变化与临床关系进行了分析，说明ＨＰＬ值不仅能直接反映胎盘功能，且能有效地反映胎儿宫内生长状态，证实血清ＨＰＬ测定是产前监护的可靠指标。

From Dec.1992 to Dec.1994 serum levels of human placental lactogen(HPL)were measured by RIA in 408 cases pregnant women(involving 156 cases of normal pregnancyand 252 cases of high risk pregnancy).It is affirmed that the measurement of HPL Ievel is reli-able index of antepartum monitoring. Results:①The normal reference value of pregnancyserum HPL level is 11.92±3.6mg/L(scoped 6.8～16 mg/L).②HPL level >6 mg/L,4～6mg/L and<4mg/L are normal,doubtful and dangerous value.③HPL level<4mg/L in theedema-proteinuria- hypertension syndrome,intrauterine growth retardation,intrauterine fetalanoxia,placental pathological changes and abnormity of bony pelvis are significently more thanthat in normal pregnant women(P<0.01～0.001).It is showed that HPL level not only di-rectly reflect placental function but also effectively reflect intrauterine fetal growth state.It isconcluded that the continuous measurement of HPL level and application of various monitor in-dices are the very best of the antepartum monitoring due to big difference between individual.