急性脑血管病发病的日节律现象探讨

DISCUS5ION ON THE ONSET DAY-RHYTHM F ACUTE CEREBROV ASCULAR DISEASE

本文对１９２例共２５９发病例次的急性脑血管病发病日节律与病灶大小进行了探讨，发现脑血管病在一日２４小时中有２个发病高峰，其第１个较大的高峰在５～１２时，尤以５～９时、特别５～７时为最高峰，第２个较小的高峰在１５～１９时，对发病的周期性函数曲线拟合方程是：Ｙ＝２１．２２＋９．４６ｓｉｎ（０．１７πｔ＋３０３）＋８．８１ｓｉｎ（０．３３πｔ＋２３８）＋ｌ．５７ｓｉｎ（０．５０πｔ＋５８），式中Ｙ为发病频数，ｔ为时间，方程Ｐ＜０．０５，拟合效果良好，还进一步对发病形成的病灶大小进行了多元相关与逐步回归分析，获得脑梗塞病灶大小的方程为：Ｔ＝６３．６２＋１０９．７０ｘ１－７９．９７ｘ２＋２．１５ｘ３，式中Ｔ为体积（ｃｍ３），ｘ１为血小板聚集率，ｘ２为血浆粘度，ｘ３为发病时间，方程Ｒ＝０．５０３４，Ｐ＜０．２，这些结果均显示了在脑血管病发病中时间因素的重要性。

This paper evaluated the onset of acute cerebrovaseular disease,its day-rhythm and the feeus size in 192 patients with total 259 episodes of the onset.The results showed that there were two peaks of the onset in 24 hours of one day,of them the first peak was frorm 5:00 to 12:00,but the highest peak was from 5:00 to 9:00,especially from 5:00 to 7:00,and the second lower peak was from 1 5:00 to 19:00.Its curvilinear fitting equation of periodic function was Y=21.22+9.46 sin(0.17 πt+303)+8.81 sin(0.33πt+238)+1.57 sin(0.50πt +58),where Y was the onset frequency and t was the time,the equation's P<0.05 and the ef-fect of fitting was satisfactory.Further,a multiple correlation and stepwise regression of the fo-cus size was made and the obtained equation was T=63.62+109.70x1-79.97 x2 +2.15 x3,where T was the forus volume(cm3),x1 was platelet aggregation rate,x2 was plasma viscosity and x3 was the onset time,the equation’s R=0.5034(P<0.2).These results showed an impor-tance of the time factor in the onset of cerebrovascular disease.