老年高血压病患者纤溶功能及血小板活化状态的改变

CHANGES OF FIBRINOLYTIC ACTIVITY AND THE DEGREE OF PLATELET ACTIVATION IN AGED PATIENTS WITH ESSENTIAL HYPERTENSION

采用抗人活化血小板α颗粒膜蛋白（ＧＭＰ－１４０）单克隆抗体ＳＬ－５ｌ和１２５Ｉ－Ｓ１２以及单克隆酶联免疫法、发色底物法测定５８例老年高血压（ＥＨ）患者血浆ＧＭＰ－１４０、血栓素Ｂ２（ＴｘＢ２）、６酮－前列腺素Ｆ１α（６－ｋｅｔｏ－ＰＧＦ１α）浓度、组织型纤溶酶原激活物（ｔ－ＰＡ）含量及活性以及纤溶酶原激活抑制物（ＰＡＩ）活性，并与２０例健康人作对照。结果表明，ＧＭＰ－１４０、ＴｘＢ２、ＰＡＩ活性显著高于对照组，６－ｋｅｔｏ－ＰＧＦ１α、ｔ－ＰＡ显著低于对照组。将所得血浆各值与动态血压（ＡＢＰ）监测各指标作单相关分析，提示ＰＡＩ、ＧＭＰ－１４０、ＴｘＢ２与２４小时收缩压、舒张压、白昼收据压、舒张压呈显著正相关，６－ｋｅｔｏ－ＰＧＦ１α与２４小时收缩压、白昼收缩压呈显著负相关。

Plasma levels of tissue type plaminoge activator(t-PA),plasminogen activatorinhibitor(PAI),pIatelet granule membrane gbcoprotein(GMP -140),thromboxane B2 (TxB2)and 6-ketoprostaglandin F1α(6-keto-PGF1α)were assayed in 58 aged patients with essential hyper-tension(EH)and in 20 control subjects.It was shown that GMP-140,TxB2 and PAI increasedsignificantly and 6-keto-PGF1αand t-PA decreased significantly in EH group than in control sub-jects.By univariable analyses,the relationship between ambulatory blood pressure(ABP)andplasma leveis of t-PA,PAI,TxB2,6-keto-PGF1α and GMP-140 were investigeted in 78 consecu-tive subjects who undewent 24 hour noninvasive ABP monitoring.It is suggested that GMP-140and TxB2 were positively correlated with average 24 hour sysytolic and diastolic blood pressure(SBP and DBP),average daytime SBP and DBP and that 6-keto-PGH1α and t-PA were negative-ly correlated with average 2 4 hour SBP and daytime SBP.