难治性癫癎与多药耐药基因表达上调
摘要
癫痫是神经系统常见、多发病症。在过去20年中,有多个新型抗癫痫药物(AED)问世并应用于临床,但仍有1/3的癫痫患者发作不能得到满意控制,药物治疗效果不良,称为难治性或耐药性癫痫。难治性癫痫耐药现象的细胞分子机制尚不完全清楚,可能为:①AED的作用靶点如钠通道或GABA受体消失或改变;②由于血脑屏障上药物转体等的变化,药物进入脑实质细胞外液量减少,这样可能血药浓度在治疗范围,但脑细胞外液中浓度不够而达不到治疗作用;③神经细胞膜上药物转运体的改变,致使细胞内液中药物量不足,药物不能有效通过细胞内机制发挥抗癫痫作用。目前已有研究显示多药耐药基因(MDR1)表达上调,其表达产物P-糖蛋白(p-gp)增多与顽固性癫痫耐药现象有关,现就这方面的研究作一综述。
出处
《临床神经电生理学杂志》
2006年第1期47-48,共2页
Journal of Clinical Electroneurophysiology
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