摘要
目的:观察丹参金对急性心肌缺血的保护作用。方法:采用垂体后叶素(P it)诱发大鼠急性心肌缺血模型、结扎左冠状动脉前降支(LAD)致麻醉犬急性心肌缺血模型,观察丹参金对急性心肌缺血的保护作用。结果:丹参金显著对抗P it诱发的大鼠心电图T波变化(P<0.05,P<0.01);抑制心肌缺血麻醉犬Σ—ST、N—ST的升高,减少CK、LDH的释放(P<0.05,P<0.01)。结论:丹参金对P it诱发的大鼠急性心肌缺血模型、左冠状动脉前降支结扎所致的麻醉犬心肌缺血具有显著地保护作用。
Objective ：To observe the protective effects of Danshenjin on acute myocardial ischemia. Methods： The acute myocardial ischemia models induced by injecting pituitrin in rats and ligating the anterior descending branch of the nearside coronary artery in dogs were established to investigate the protective effects of Danshenjin on acute myocardial ischemia. Results ：Danshenjin was able to reduce the fluctuation of T waves in cardiogram（ P 〈 0. 05, P 〈 0.01 ） in rat induced by pituitrin significantly and inhibit the increase of the S - T segment （E - ST, N - ST）, decrease the release of cardiac CK and LDH （ P 〈 0. 05 ,P 〈 0.01 ）. Conclusion： Danshenjin can remarkably protect acute myocardial ischemia models of Pit induced and the anesthetic dogs mediated by ligating coronary artery.
出处
《中医药学刊》
2006年第2期302-304,共3页
Study Journal of Traditional Chinese Medicine
