急性冠脉综合症诊断中检测心肌肌钙蛋白I肌红蛋白及肌酸激酶同工酶及超敏C-反应蛋白的意义

Measurement of hs-C-Reactive Protein,Cardiac Troponin I,Creatine Kinase Isoenzyme MB and Myoglobin in the Diagnosis of Acute Coronary Syndrome

目的:探讨实验室诊断在急性冠脉综合症早期诊断中的意义。方法:采用化学发光法测定68例冠心病(CHD)患者及40例正常对照组超敏C反应蛋白(hs-HS-CRP)、心肌肌钙蛋白I(cT-nI)、肌红蛋白(Mb)、肌酸激酶同工酶(CK-MB)的阳性率。结果:CHD组患者的hs-HS-CRP、cTnI、Mb、CK-MB的阳性率均明显高于正常对照组(P<0.05)。CHD组又分为3组,急性心机梗死组(AM I)20例、不稳定型心绞痛组(UA)28例、稳定型心绞痛组(SA)20例。AM I组患者的hs-HS-CRP、cTnI、CK-MB和Mb阳性率均明显高于SA组(P<0.01);UA组hs-CRP和cTnI阳性率均明显高于SA组(P<0.01),但两组间CK-MB和Mb阳性率相比无显著差异(P>0.05)。结论:冠心病发生与hs-HS-CRP和cTnI的增高相关。

Objective： To investigate the early diagnosis of acute coronary syndrome. Methods： By using irorouneturbidity test and enzyme for rapid quantification, hs - C - reactive protein （ hs - HS - CRP）, cardiac troponin Ⅰ（ cTnI）, creatine kinase isoenzyroe MB （ CK - MB ） and royoglobin （ Mb ） were measured in 68 patients with acute coronary syndrome （ ACS group ） and 40 healthy volunteers （ control group ）. Results： The positive rate of hs - HS - CRP, cTnI, CK - MB and Mb in ACS group was significantly higher than those in control group （P 〈 0.05 ）. The patients with ACS were divided into 3 groups： 25cases of acute roy coeardial infarction （ AMI group） , 23 cases of unstable angina pectoris （ UA group ） and 20 cases of stable angina pectoris（ SA group）. The positivre rate of hs- HS- CRP, cTnI, CK -MB and Mb in the AMI group were significantly higher than those in the SA group （ P 〈 0.05 ）, but there was no siginificant difference in the positive rate of of CK - MB and Mb between UA group and SA group. Conclusion： There was a significant correlation between the evalation oi hs - HS - CRP, cTnI and the risk of ACS events.