急性胰腺炎并发胰性脑病和韦尼克脑病

Pancreatic and Wernicke encephalopathy in acute pancreatitis：8 cases report

目的探讨急性胰腺炎（AP）并发胰性脑病（PE）和韦尼克脑病（WE）的临床特征和治疗方法。方法回顾性分析8年来收治AP病人394例的临床资料。结果AP中重症急性胰腺炎（SAP）78例，发生脑病8例，其中PE5例，WE3例。死亡3例。PE2例，WE1例，2例WE经注射维生束B1而治愈。结论PE多发生在SAP的早期或病情反复时；WE发生于SAP或AP的恢复期。禁食时间长、反复呕吐及全胃肠外营养中未补充维生素B1是导致急性胰腺炎者维生素B1缺乏，从而发生WE的重要原因。

AIM To investigate the clinical characteristics and treatment of pancreatic encephalopathy （PE） and Wernicke encephalopathy（WE）. METHODS A retrospective study was conducted on 394 cases of acute pancreatitis treated in the past 8 years. RESULTS Severe acute pancreatitis（SAP）was found in 78 cases, in which,5 cases had PE（2 died）and 3 cases had WE（1 did not receive Vitamin B1 treatment and died）. CONCLUSIONS PE occurred in early stage or recrudescence of SAP,while WE usually occurred in convalescent stage of SAP/AP. Vitamin B1 insufficency might be the main causative factor for WE.