五羟色胺在胃肠道功能性疾病中的研究现状被引量：59

Current status of hydroxytryptamine in functional gastric intestinal diseases

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摘要五羟色胺(5-HT)是参与调节胃肠道运动和分泌功能的重要神经递质,95%来源于肠道黏膜层的嗜铬细胞.胃肠道主要有5-HT1、5-HT2、5-HT3、5-HT4、5-HT7受体.5-HT在发挥生理作用后通过肠黏膜上皮细胞膜上的5-HT转运体(SERT)再摄取至细胞内灭活.SERT基因5’启动子区存在多态性位点5-HTTLPR,形成L/L、L/S、S/S三种等位基因类型,S型较L型转录效率降低.胃肠道通过肠神经系统自主、协调地完成蠕动、分泌反射.肠嗜铬细胞释放5-HT,激活黏膜下传入神经纤维,通过肠神经系统,调节局部的兴奋和抑制.5-HT信号系统异常可导致胃肠道动力及分泌功能异常、内脏高敏感性,与慢性便秘、肠易激综合征、腹泻及功能性消化不良等胃肠道功能性疾病密切相关.对SERT表达在肠易激综合征发病机制中作用的研究是目前的热点.SERT基因多态性与肠易激综合征各型间可能存在联系.

作者丁健华傅传刚赵荣华

机构地区中国人民解放军第二军医大学长海医院肛肠外科美国克利福兰基金会佛罗里达医院肛肠外科

出处《世界华人消化杂志》 CAS 北大核心 2005年第20期2405-2408,共4页 World Chinese Journal of Digestology

基金教育部留学回国人员科研启动基金课题教外司留[2001]345号~~

关键词五羟色胺五羟色胺受体五羟色胺转运体胃肠道功能性疾病肠黏膜上皮细胞肠易激综合征 5-HT3 功能性消化不良肠神经系统分泌功能

分类号 R57 [医药卫生—消化系统]

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