1[1]Krieg AM,Yi AK,Matson S,et al.CpG motifs in bacterial DNA trigger direct B-cell activation.Nature 1995; 374(6522):546-549.
2[2]Sato Y,Roman M,Tighe H,et al.Immunostimulatory DNA sequences necessary for effective intradermal gene immunization.Science 1996; 273(5273):352-354.
3[3]DNA Vaccine web site:http://www.Genweb.com/Dnavax/dnavax.html
4[4]Bird AP.DNA methylation and the frequency of CpG in animal DNA.Nucleic-Acids-Res 1980; 8 (7):1499-1504.
5[5]Jones PA,Rideout WM 3rd,Shen JC,et al.Methylation,mutation and cancer.Bioessays 1992; 14(1):33-36.
6[6]Klinman DM,Yi AK,Beaucage SL,et al.CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6,interleukin 12and interferon gamma.Proc-Natl-Acad-Sci-U-S-A 1996; 93 (7):2879-2883.
7[7]Ballas ZK,Rasmussen WL,Krieg AM.Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA.J-Immunol 1996; 157(5):1840-1845.
8[8]Lipford GB,Sparwasser T,Bauer M,et al.Immunostimulatory DNA:sequence-dependent production of potentially harmful or useful cytokines.EurJ-Immunol 1997; 27 (12):3420-3426.
9[9]Chu RS,Targoni OS,Krieg AM,et al.CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity.J-Exp-Med 1997; 186(10):1623-1631.
10[10]Oxenius A,Martinic MM,Hengartner H,et al.CpG-containing oligonucleotides are efficient adjuvants for induction of protective antiviral immune responses with T-cell peptide vaccines.J-Virol 1999,73(5):4120-4126.
4萨姆布鲁克 J,拉塞尔 D W.分子克隆实验指南[M].3版.黄培堂,王嘉玺,朱厚础,等译.北京:科学出版社,2002:96—99;1232—1236.
5Tischerl, Rasch R, Tochtermann G. Characterisation of papovavirus and picornavirus like particles in permanent pig kidney cell lines [J]. Zentralbl Bakteriol Parasitenkd Infektionskr Hyg Abt Orig, 1974,226 : 153-167.
6Kennedy S, Moffertt D, McNeilly F, et al. Reproduction of lesions of postweaning multlsystemic wasting syndrome by infection of conventional pigs with porcine circovirus type 2 alone or in combination with porcine parvovirus[J]. Comp Pathol, 2000,122 : 9-24.
7Segales J,Pineiro C, Lampreave F,et al. Haptoglobin and pigmajor acute protein are increased in pigs with postweaning multisystemic wasting syndrome (PMWS) [J]. Res Vet Sci, 2004,77(2) : 177-184.
8Ellis J A,Bratanich A,Clark E G,et al. Coinfection by poxcine circoviruses and porcine parvovirus in pigs with naturally acquired postweaning multisystemic wasting syndrome[J]. Vet Diagn Invent, 2000,12 ( 1 ) : 21-27.
9Resendes A,Segales J, Balasch M, et al. Lack of an effect of a commercial vaccine adjuvant on the development of postweaning multisystemic wasting syndrome (PMWS) in porcine circovirus type 2 (PCV2) experimentally infected conventional pigs[J]. Vet Res,2004,35(2) :243-253.
10Blanchard P, Mahe D, Cariolet R, et al. Protection of swine against post-weaning multisystemic wasting syndrome(PMWS) by porcine circovirus type (PCV2) proteins[J]. Vaccine, 2003,21(31):4565-4575.