摘要
目的探讨雷帕霉素药物洗脱支架(Cypher)在急性ST段抬高心肌梗死急诊经皮冠状动脉介入治疗(PCI)中应用的安全性和有效性。方法选择2002年11月至2004年12月间的急性ST段抬高心肌梗死患者168例,于发病12h内行急诊PCI治疗,于梗死相关血管的靶病变置入Cypher支架。记录1个月和6个月随访终点时的主要心脏不良事件(包括死亡、再发心肌梗死、靶血管再成形等)发生率、支架内血栓发生率、支架内再狭窄发生率。结果168例患者急诊PCI治疗均获得成功。168支梗死相关血管的171处罪犯病变共置入175枚Cypher支架,未发生与介入治疗有关的并发症。1个月随访终点时死亡3例(死亡率1.8%);支架内亚急性血栓1例;主要心脏不良事件发生率2.4%。6个月随访终点时死亡4例(死亡率2.4%);主要心脏不良事件发生率4.2%;支架内血栓发生率1.2%;支架内再狭窄发生率1.8%。结论药物洗脱支架(Cypher)在急性ST段抬高心肌梗死急诊PCI中应用与普通支架一样有较强的安全性和有效性,并可以明显降低再狭窄率。
Objective To investigate the feasibility, safety and efficacy of Cypher drug-eluting stent implanted after the emergency percutaneous coronary intervention （PCI） in patients with ST-segment elevation myocardial infarction （STEMI）. Methods From Nov. 2002 to Dec. 2004,186 patients with STEMI treated by emergency PCI were included into this study. The incidence of major adverse cardiovascular event （MACE）, stent thrombosis and restenosis were evaluated during 6 months follow-up after PCI. Results One hundred and sixty-eight patients were successfully treated by emergency PCI and there were no complication during the procedure. The rates of successful treatment were 100%. One hundred and seventyfive Cypher drug-eluting stents were successfully implanted into 171 target lesions. There was one case with acute stent thrombosis among 186 patients, and the MACE and mortality were 2.4% and 1.8%, respectively, during the first one month follow up. Six months later, the MACE was 4. 2% and the mortality was 2.4%. The in-stent thrombosis and restenosis rates were 1.2% and 1.8%, respectively, when evaluated by angiography and clinic follow up at six months after PCI. Conclusion Implanting a Cypher drug-eluting stent in STEMI patients during emergency PCI is as safe and effective as a conventional bare stent. Cypher drug-eluting stent can reduce restenosis rate and MACE in STEMI patients treated with emergency PCI.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2005年第12期1099-1101,共3页
Chinese Journal of Cardiology
