博乐欣治疗抑郁症的临床疗效研究

A comparative sfudy of venlafaxine and imipramine for deprossive patients

目的:验证博乐欣治疗抑郁症的疗效及安全性。方法:将70例抑郁症患者随机分博乐欣组(40例)和丙咪嗪组(30例),进行照研究,两药治疗剂量均为150mg^300mg/d,疗程4周。疗效指标包括汉密顿抑郁量表(HAMD)、汉密顿焦虑量表(HAMA)、临床总体评定量表(CGI)。不良反应指标为不良反应量表(TESS)及有关实验室检查。结果:治疗结束时,两组HAMD和HAMA评分较入组时均显著减低(P<0.01;临床总有效率:博乐欣组82.5%,丙咪嗪组77%,两组疗效差异无显著性;博乐欣起效时间在治疗第一周末,丙咪嗪在治疗第二周末.博乐欣组的不良反应较丙咪嗪组少而轻,常见的有头晕、口干、胃肠不适等,口干、便秘、排尿困难的发生率显著小于丙咪嗪组(P<0.01)。结论:博乐欣治疗抑郁症有效,不良反应少而轻。

Objective The dun of this study was to etermine the officacy and safety of ven afaxine to the patients with depression Methods Patients who met CCMD - 3 criteria for depressive episode were randonizde into two groups： venlafaxine group （ n = 40） and imipramine group （n= 30）. The range of dosane for the two experiment drugs was 150- 300rag/d, the treatment duration was4 weeks. The HAMD, HAMA, CGI, TESS and related lab tests were employed for assessing the treatment effeciteness and side effects. Results At the end of treatments, the scores of HAMA in both treatment groups decreased significantly compared with baseline （P 〈 0.01）. Total clinical effective rates were 82.5% in venlafaxine group and 77% in imipramine group, which was no significant difference between two groups. However , patients in venlafaxine group, reported much tewer side effects than those in imipramine group, especially in the items of dry month, constipation, and urinary distress on TESS （ （P 〈 0.01 = ） . Condusion Venlafaxine is an effectiye antidepressants, with less side effects and better safety safety compared with imipramine.