摘要
AIM: To investigate the relationship between certain biochemical parameters of lipid metabolism in the serum and steatosis in the liver.METHODS: The grade of steatosis (0-3) and histological activity index (HAI, 0-18) in liver biopsy specimens were correlated with serum alanine aminotransferase (ALT), total cholesterol and triglyceride levels in 142 patients with chronic hepatitis C (CH-C), and 28 patients with non-alcoholic fatty liver disease (NAFLD) without hepatitis C virus (HCV) infection. The serum parameters were further correlated with 1 797 age and sex matched control patients without any liver diseases.RESULTS: Steatosis was detected in 90 out of 142 specimens (63%) with CH-C. The ALT levels correlated with the grade of steatosis, both in patients with CH-C and NAFLD (P＜0.01). Inserting the score values of steatosis as part of the HAI, correlation with the ALT level (P＜0.00001) was found. The triglyceride and cholesterol levels were significantly lower in patients with CH-C (with and without steatosis), compared to the NAFLD group and to the virus-free control groups.CONCLUSION: Our study confirms the importance of liver steatosis in CH-C which correlates with lower lipid levels in the sera. Inclusion of the score of steatosis into HAI, in case of CH-C might reflect the alterations in the liver tissue more precisely, while correlating with the ALT enzyme elevation.
AIM： To investigate the relationship between certain biochemical parameters of lipid metabolism in the serum and steatosis in the liver. METHODS： The grade of steatosis （0-3） and histological activity index （HAI, 0-18） in liver biopsy specimens were correlated with serum alanine aminotransferase （ALT）, total cholesterol and triglyceride levels in 142 patients with chronic hepatitis C （CH-C）, and 28 patients with non-alcoholic fatty liver disease （NAFLD） without hepatitis C virus （HCV） infection. The serum parameters were further correlated with 1 797 age and sex matched control patients without any liver diseases. RESULTS： Steatosis was detected in 90 out of 142 specimens （63%） with CH-C. The ALT levels correlated with the grade of steatosis, both in patients with CH-C and NAFLD （P〈0.01）. Inserting the score values of steatosis as part of the HAI, correlation with the ALT level （P〈0.00001） was found. The triglyceride and cholesterol levels were significantly lower in patients with CH-C （with and without steatosis）, compared to the NAFLD group and to the virus-free control groups. CONCLUSION： Our study confirms the importance of liver steatosis in CH-C which correlates with lower lipid levels in the sera. Inclusion of the score of steatosis into HAI, in case of CH-C might reflect the alterations in the liver tissue more precisely, while correlating with the ALT enzyme elevation.
基金
Supported by the grant from the Hungarian Ministry of Education, No.NKFP-1 A/0023/2002 National Research Development Projects and grant from the Hungarian National Scientific Research Fund, No.OTKA T037838
