抢救危重病人的心血管循环反馈治疗仪及动物实验

An Cardiovascular Automatic Feedback Control Instrument for Rescuing the Critical Patients and Animal Experiments

目的:国内外医疗仪器的发展正朝着自动化、智能化、模块化方向发展,但主要集中于诊断方面,用于治疗仪器极少,本仪器目的是为危重病人的抢救。材料与方法:本仪器是综合临床成功经验设计研制,程序结合实验中数学模型汇编,通过在线闭环自动检测,直接、快速、连续、高密度地采集血压,肺毛细血管契压(PCW)、心率等重要生理参数,经压力传感器、A/D转换卡实时连续地输入计算机.通过用户界面人机对话,由医生选择药物,经数学模型及程序的运算,D/A转换器输出指令经输液器控制给药量,药物在机体反应及时、迅速地反馈回计算机,计算机不断更新计算结果,以此调节给药速率及剂量。此外该系统还有监控、报警、故障自诊断、智能化运行等特点。结果:通过八只犬的实验表明,计算机取样及时、准确、快速。给药结果证明能按照预期设计要求达到治疗目的。结论:传统的临床治疗方法从收集病人数据到决定准确的给药量反馈过程太长,还有不少人为及计算的干扰和误差,因此抢救成功率极低。该系统从获取血压变化到多次反馈调整给药整个周期短、计算准确,疗效可靠。是一个很有发展前景的抢救危重病人的仪器,目前该仪器仍待进入临床评价。

Objective： To design and develop a cardiovascular automatic feedback control instrument for rescuing the vital patients and animal experiments. Materials and Methods： The instrument is based on the abundant and successful clinic experience, the program was made by combining with mathematics model which came from the data of experiment. The blood pressure was collected and gathered online in direct, fast, continuous, high density through close ring measure automatically. BP, PCW, rate of heart beat etc. important physiological parameters were input into computer real-time in succession by pressure sensor, A/D change card. The drugs were chosen by the doctor through user＇s interface of human-machine dialogue, passing the operation of mathematics model and program, outputting orders by D/A converter to control the amount of medicine given by transfusion system, and the responses to medicine in organism were rapidly feedback to computer in time by at, tomatic detection system of the close ring online feedback, the computer brought in constant renewal in the result of calculation, so as to regulate the speed and dosage of the medicine. In addition, this system also has the characteristics such as controlling, alarm, trouble shorting, operating intelligently. Results： The results of eight-dog experiment indicated： the computer takes a sample promptly, accurately and fast, it can avoid some errors made by people and the deficiency of sample spacing interval pass long. It demonstrated that results of experiments can be expected as the goal of medicine treating in designing requirement. So practicability is strong, the high-tech content is high, it can be predicted that it is applied to rescue the vital patient clinically in the future. Conclusions： The course of collectting patient＇s data feedback to decision accurately giving medicine is too long in traditional clinical method, It causes errors and interference easily and lead extremely low success rate of rescuing, In animal experiments, it was found that thewhole cycle from taking exampling BP to adjust to the amounts of medicine is short （2-5 minutes）. Calculating accuracy and curative effect is reliable. The doctors were told to change medicine timely when some medicine is invalid. It can race against time clinically. This instrument has a good future for rescuing vital patients, at present, the instrument still wait to receive clinical appraisal.