脑性瘫痪儿童胃食管返流的研究

Observation on gastroesophageal reflux in children with cerebral palsy.

【目的】探讨脑性瘫痪对胃食管返流的影响,为临床及时干预提供依据。【方法】利用便携式食管24h连续PH动态监测仪分别检测20例脑性瘫痪组儿童及20名无胃食管返流症状儿童的24 h食管PH值。【结果】脑性瘫痪组儿童的各项参数均明显高于对照组,两组总PH值<4的时间百分比(%)脑性瘫痪组、对照组分别为(15.89±11.04)与(1.88±1.01)、酸性返流发生的总次数为(次/24 h)309.02±165.60与14.73±7.20、返流持续超过5 min的次数为(次/24 h)5.64±3.52与1.02±0.90、返流持续的最长时间(min)为23.38±13.40与4.50±1.90、DeMeester评分为61.42±58.15与2.20±3.50,差异均有非常显著性(P<0.01)。【结论】脑性瘫痪可以引起胃食管返流,应及时给予干预治疗。

[Objective] To investigate the effects of cerebral palsy on gastroesophageal reflux disease （GERI））. [Methods] 24-hour esophageal PH monitoring were performed in 20 cerebral palsy children and 20 asymptomatic children respectively. [Results] The 24-hour esophageal PH monitoring revealed that the varies of acid reflux in cerebral palsy group were all dramatically higher than those of controls. The reflux index（%） was 15.89± 11.04/1.88±1.01 （cerebral palsy group/control group）, the number of reflux episodes was（times/24 h） 309.02± 165.60/14.73±7.20, the number of reflux over 5 minutes times / 24h was 5.64± 3.52 / 1.02±0.90, the duration of the longest episode （ min ） was 23.38±13.40/4.50±1.90, DeMeester score was 61.42±58.15/12.20±3.50. The differences were all significant（P〈0.01 ）. [Condusion] By the help of 24-hour esophageal PH monitoring, the authors can get information about gastroesophageal motility of cerebral palsy children. The gastroesophageal reflux increases in the cerebral palsy children, early intervention should be given.