摘要
糖尿病肾病(DN)是糖尿病患者最常见的微血管并发症之一,其发病机制尚未明确,可能与蛋白激酶C(PKC)的激活、氧化应激(ON)、转化生长因子β1(TGFβ1)、血管紧张素Ⅱ、一氧化氮(NO)等因素有关。近年研究发现PKC的激活可能是DN多种发病机制相联系的共同纽带。
Diabetic nephropathy (DN) is one of the common micro-vascular complications in diabetic patients. Its definite pathogenic mechanism is unknown and may be related to protein kinase C (PKC) activity , oxidation stress (OS) , transforming growth factorβ1 (TGF-β1) , angiotensin Ⅱ , nitric oxide (ON) . Iu recent years, it has been found that PKC activity may share a common link in various pathogenic mechanism of DN.
出处
《医学综述》
2006年第3期154-156,共3页
Medical Recapitulate
关键词
蛋白激酶C
糖尿病肾病
Protein kinase C (PKC)
Diabetic nephropathy (DN)