抵抗素、肥胖和2型糖尿病

Resistin Obesity and Type 2 Diabetes

2型糖尿病以胰岛素靶组织的胰岛素抵抗为特征,在2型糖尿患者群中有80%～85%的个体有肥胖症。抵抗素(Resistin)又称为脂肪组织特异性的分泌因子(ADSF),是新近在鼠类脂肪组织中发现的由脂肪细胞特异性分泌的多肽类激素,在鼠类可以引起胰岛素抵抗,肥胖小鼠体内的抵抗素水平升高,因而被认为是连结肥胖和2型糖尿病之间的一个中介分子。抵抗素最初在小鼠的白色脂肪组织中被发现,近来很多研究在人类的许多组织中发现也有抵抗素的表达,并对其结构、功能等进行了一系列的研究。本文针对抵抗素与肥胖和2型糖尿病间关系的研究作一综述。

Type 2 diabetes is characterized by the inability of target tissues to rsspond normally to insulin, and there are 80 percent to 85 percent indivaduals who are obese. Resistin（ adipecyte-specific secretory factor, ADSF） is a peptide hormone secreted primarily from adipose tissue in rodents. Resistin was detected in circulation at a higher level in obese mice and the mice treated with recombinant resistin had increased insulin resistance, Resistin was thereby thinked to be a link between obesity and diabetes. Resistin was primarily found in white adipose tisstue of mice, but recent researchers have shown that it is expressed in many other human tissues and investigated its structure and function, This review focused on the relationship between resistin, obesity and type 2 diabetes.