睫状神经营养因子与视网膜神经节细胞

CNTF and Retinal Ganglion Cells

睫状神经营养因子作为神经营养因子家族中的重要成员,广泛分布于中枢神经系统。视神经与视网膜是中枢神经系统的一部分。视网膜神经节细胞在视觉通路中起着重要的传导作用。睫状神经营养因子作为一种非靶源性神经营养因子,在视网膜神经节细胞的生长发育过程中,起着重要的调控作用;同时睫状神经营养因子对于损伤的视网膜神经节细胞有促进其存活及轴突再生的作用。

As an important member of the families of nanrotrophic factors, ciliary neurotrophic factor （CNTF） is distributed in central nervous system widely. Optic nerve and retina are parts of central nervous system. Retinal ganglion cells play an important role in visual conduction . As a non-target-derived neurotrophic factor, CNTF plays an important role in regulating the growth and development of retinal ganglion cells. Meanwhile, CNTF can also promote the survival and axonal regeneration of the injured retinal ganglion cells.