老年恶性肿瘤患者纤维蛋白原含量的临床观察

Clinical significance of plasma fibrinogen in elderly patients with malignant tumor

目的探讨血浆纤维蛋白原(fibrinogen,FIB)水平与老年人恶性肿瘤的关系,并观察其在肿瘤化疗过程中的变化情况。方法采用CA-500SERIES全自动血栓止血测定仪测定58例老年恶性肿瘤患者的血浆FIB水平,及其化疗后的FIB水平,行相关性分析。并以40例健康体检老年人为对照组。结果老年恶性肿瘤患者血浆FIB水平明显高于对照组(P<0·01),但不同类型肿瘤患者FIB含量无统计学差异(P>0·05)。治疗后缓解的患者血浆FIB含量较前明显降低(P<0·01),未缓解者治疗前后FIB含量无统计学差异(P>0·05)。结论血浆FIB水平在恶性肿瘤的辅助诊断及疗效判断方面有一定临床意义。

Objective To study the variation of plasma fibrinogen （FIB） in aged patients with malignant tumor, and to explore its clinical significance. Methods CA-500 SERIES automated coagulation analyzer was used to detect FIB content in 58 aged patients with malignant tumor before and after treatment. Results FIB level increased obviously in patients with malignant tumor than that in control group（ P 〈 0. 01 ）, but there was no significant difference in different types of malignant tumor（ P 〉 0. 05 ）. FIB content decreased significantly in patients with curative effect （ P 〈 0. 01 ）, otherwise it didn＇t change in patients without effect（P 〉 0. 05 ）. Conclusions FIB level plays an important role in the diagnosis and evaluation of therapy in aged patients with malignant tumor.