基因MTA1在喉癌中的表达和意义

Correlation between expression of the MTA1 gene and carcinomas of larynx

目的:研究肿瘤转移相关基因Mta1(metastasis-associated gene)表达与喉癌淋巴结转移的关系。方法:应用RT-PCR技术,对30例喉癌组织、12例喉癌颈部淋巴结和10例正常喉部组织,进行了Mta1mRNA表达的检测。结果:有转移喉癌原发灶Mta1mRNA高表达率为100%(8/8),无转移为22.7%(5/22),P<0.01;有癌转移淋巴结高表达率为87.5%(7/8),无癌转移为0(0/4),P<0.05。30例喉癌有13例Mta1mRNA高表达,高表达率为43.3%。结论:Mta1mRNA表达与喉癌淋巴结转移呈相关关系。基因Mta1可成为判断喉癌转移有价值的指标。

Objective： To study the relation between Mtal gene（metastasis associated gene, meta gene）and lymph node metastasis of laryngeal carcinomas . Method： Reverse transcription polymeras chain reaction（RT-PCR） technique was used to detect the expression of Mtal mRNA in 30 carcinoma of larynx tissue cases, 12 lymph nodes and 10 normal larynx tissue cases. Result：The frequency of MTA1 overexpression was 100%/40 （8/8） in primary carcinomas of larynx with metastasis but only 22. 7% （5/22） in thoes without metastasis（P〈0.01）. Expression of MTA1 was 87.5% （7/8） in lymph nodes with metastasis but only 0（0/4） in thoes without metastasis（P〈0.05）. The frequency of Mtal overexpression was 43.3% （13/30） in primary carcinomas of larynx. Conclusion：Our data suggest that the overexpression of the MTA1 gene correlates with lymph node metastasis of carcinomas of larynx. Mtal gene will probably become a valuahle gene for judging metastasis of laryngeal carcinoma.