摘要
IUC中的患者常有紧张、焦虑等情绪，尤其是术后气管切开或留置气管导管患者，除了上述情绪外，尚有不适、忧虑甚至疼痛的不良感受。而大手术后，ICU中通常使用阿片类药物缓解患者术后疼痛，但观察到有时单用阿片类药物镇静效果不甚理想。为了消除患者的焦虑，增加舒适感，我们在ICU中观察了咪达唑仑和芬太尼的联合用药对此类患者的镇静程度。
Objective To study it can maintain sedation effectively that combined midazolam and fentanyl. And the study refers to the patients whose tracheostomy the or endotracheal tube remained after the operation. Methods Thirty patients were divided into 3 groups randomly, who undergo oral and maxiUofacial tumor surgery. After the operation, they were in ICU with trachemostomy tube or endotracheal tube remained. Group Ⅰ , controled group, were administered transvenous diazepam 0.1 - 0.2mg/kg; Group Ⅱ, transvenous midazolam 0. 1mg/kg; Group Ⅲ, combined fentanyl 1μg/kg per hour and midazolam 0.05mg/kg. HR, MAP, ECG, SPO2, PetCO2 were monitored and recorded. Analyze the data and compare OAA/S premedicine with postmedicine. Result Group Ⅰ ：the patients had obvious anxiety reaction. Group Ⅱ and Group re：the patients had no obvious anxiety reaction. And Group Ⅲ can maintain sedation.
