化痰活血方对高脂血症大鼠血液流变学的影响

The Effect of Huatan Huoxue Fang on Blood Lipid Metabolism and Hemorheology in Experimental Hyperlipidemia Rats

目的观察化痰活血方对高脂血症大鼠血脂和血液流变学的影响。方法采用高脂乳剂建立大鼠高脂血症模型后给予化痰活血方,检测大鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-c)、高密度脂蛋白(HDL-c)、血液流变学各项指标。结果化痰活血方能显著降低高脂血症大鼠血中TC、TG、IDL-c,显著增加HDL-c、HDL2-c的水平,与模型组比较有显著性差异(P<0.05或P<0.01):血液流变学各项结果显示该方能明显降低高脂血症大鼠高、低切变率下的全血粘度(ηb)、血浆粘度(ηp)、红细胞压积(HCT)。结论化痰活血方不仅对高脂血症大鼠的血脂代谢紊乱具有较好的调节作用,而且能改变血液流变学特性。

Objective： To observe the effect of Huatan Huoxue Fang on the blood lipid metabolism and Hemorheology in experimental hyperlipidemia rats. Methods： Feeding with lipidemia emulsion to establish the hyperlipidemia rat model for detecting the various indexes of lipid and hemorheology including the total cholesterol （TC） , triglyceride （TG）, low density lipoprotein cholesterol （LDL-c）, high density lipoprotein cholesterol （HDL-c）, the blood viscosity（ηb）, plasma viscosity （ηp） and hematocit （HCT）. Results： Huatan Huoxue Fang could obviously lowered the level of TC, TG, LDL-c, and increases the levels of HDL-c. HDL2-c in rats＇ blood, showing obvious difference from the model group （P〈0. 05 or P〈 0. 01） . The various results of hemorheology show that Huatan Huoxue Fang can clearly reduce the blood viscosity（ηb）, plasma viscosity （ηp） and hematocit （HCT） under the rate of high and low exchange. Conclusion： Huatan Huoxue Fang not only can effectively reduces metabolism of the lipid, and prevent and cure hyperlipidemia, possess obvious effect of regulating the disorder of lipid circulation of hyperlipidemia rats, but also changes the characteristic of hemorheolngy, so that the condition of blood thickness, viscosity and RBC mass can be improved.