血管内皮生长因子与胸外伤肺水肿相关性研究

Research on the Relationship between the Vascular Endothelial Growth Factor and Pulmonary Edema of Chest Trauma

目的探讨血管内皮生长因子(VEGF)与胸外伤肺水肿的关系。方法将家兔分为受伤前和受伤后1、2、4、12、24、48、72h8组,用ELISA方法,观察家兔胸外伤后血浆VEGF的变化和肺组织的病理变化。结果家兔胸外伤后2h,部分肺组织轻度水肿,伤后24h肺组织明显水肿,伤后72h肺水肿减轻。血浆VEGF在胸外伤后均升高,以伤后24h、48h、72h与伤前比较差异有显著性(P<0.01),伤后24h、48h与伤后1h、2h比较,差异亦有显著性(P<0.01)。结论家兔胸外伤后血浆VEGF的变化与肺水肿的程度基本一致。

Objective. To investigate the relationship between the vascular endothelial growth factor （VEGF） and pulmonary edema of chest trauma. Methods： Rabbits were divided into eight groups, included non-injury group and groups of 1 hour, 2 hours, 4 hours, 12 hours, 24 hours,48 hours, 72 hours after injury. With the method of ELISA, the plasma VEGF and the pathology of the lung of the rabbits were observed. Results： For the rabbits, the lung become edema partly at 2 hours after injury, remarkably at 24 hours after injury and relieved at 72 hours after injury. The VEGF are higher in the injury groups than that in the non-injury group, and only remarkably higher in the 24 hours, 48 hours and 72 hours groups （P〈0. 01）. Also the VEGF is remarkably higher in the 24 hours and 48 hours groups than that in the 1 hour and 2 hours groups （P〈0. 01）. Conclusion： The plasma VEGF accorded with the pulmonary edema in the rabbits of chest trauma.