抑肽酶在体外循环术中的应用

The use of Aprotinin in under Cardiopulmonary Bypass

１０１例各种心脏直视手术病例在体外循环中应用抑肽酶，另以同期５２例心脏直视手术病例作为对照，研究大剂量抑肽酶在心脏直视手术中的作用，用药组转流结束后创面较对照组干燥，手术止血时间缩短，术中失血减少，术后２４小时出血量减少约５０％（用药组３１６±１１４ｍｌ，对照组５９８±１９７ｍｌ）；库血输入量抑肽酶组亦比对照组用量少（用药组４６８±１４８ｍｌ，对照组７８３±１２２ｍｌ）。大剂量抑肽酶在体外循环中的应用是安全有效的，它明显减少术中、术后的出血及库血用量。

Aprotinin was used in 101 cases under went cardiopulmonary bypass(CPB).Another 62 patients were as controls.The results indicated that the reduction of postoperative bleeding was impressive.The time needed for haemostasis and blood loss during operation were reduced.The amount of postoperative bleeding in 24 hours was reduced to 50%(group A 316±114ml,group B 598±197ml).The banked blood needed was lower in group A(468±148ml)than that in group B(783±122ml). In conclusion,we believe that the use of high dose Aprotinin is safe and effective.It decrease blood loss and reduces the need for banked blood in postoperative period.