若干植物生长控制剂衍生物的细胞毒作用研究

A STUDY ON THE CYTOTOXIC ACTION OF SEVERAL DERIVATIVES OF PLANT GROWTH REGULATORS

我们研究了19种有生物活性载体(磺胺、9-氨吖啶、对氨水杨酸及异烟肼)的植物生长抑制剂(4氯或2,4—双氯或2,4,5一三氯苯氧乙酸,2,3,5一三氯苯甲酸或α—蔡乙酸)衍生物在体外对低分化鼻咽癌细胞株CNE_2生长的抑制作用。属于含二或三氯的苯氧乙酸与磺胺类或9—氨吖啶的结合物,在100μg/ml浓度下,对细胞生长的抑制率>50％者有9种药物,>80％者有5种,其IC_(50)已测定,效力最强的2,4一二氯苯氧乙酰9—氨基吖啶(2,4—D—ACD的IC_(50)为4.58μg/ml,有进一步作体内抗癌作用研究的价值。

The growth inhibitory action of 19 derivatives of plant growth regulators ( 4- choro or 2,4- dichloro- or 2,4,5- trichloro-phenyloxoacetic acid ; 2,3,5- trichloroben-zoic acid ; α - naphthyla cetic acid ) with biological active carriers ( sulfonamides, 9 - aminoacridine, p-aminosalicylic acid, isoniazide ) on poorly differentiated nasopharyngeal carcinoma cell line CNE 2 was studied. At the concentration of 100 μg/ml 9 compounds showed cell growth inhidition rate>50%, 5 compounds >80%. They are the derivatives of di-or tri-choloro-phenyloxoacetic acid with sulfonamides or 9 -aminoacridine. Their IC 50's have been determined. The most potent one is 2,4 - dichloro-phenyloxoacetyl-amino-ac-ridine with an IC50 of 4.58 μg/ml. It is worth while to further study its in vivo antitumor activity.