摘要
报道听觉ｏｄｄｂａｌｌ序列测定３０例糖尿病和３０例年龄、性别和教育程度相匹配的正常对照组的事件相关电位（ＥＲＰ），同时进行认知能力３０题试验（ＣＣＳＥ）和简易智力状态试验（ＭＭＳＥ）。结果病人组Ｎ２和Ｐ３潜伏期较对照组显著延长（Ｐ＜０．００５），Ｐ３波幅亦较对照组降低（Ｐ＜０．０５），总异常率为２４％。虽然ＣＣＳＥ和ＭＭＳＥ两组结果经统计处理无显著性差异，但电生理学提示部分糖尿病患者很可能存在在认知功能障碍。对认知功能障碍的检测，ＥＲＰ是一项敏感、客观而又简便的电生理学检测方法。
Event-related potentials(ERP) were studied by auditory oddball paradigm in 30 diabetic patients and the same number of normal subjects with matched age,sex and degree of education.Cognitive Capacity Screening Examination (CCSE) and Mini-Mental State Examination (MMSE) were also examined.The results showed that the latencies of wave N2 and P3 prolonged and the amplitude of wave P3 decreased significantly in patient group,the abnormality rate was 24%. Although no significant differencies by CCSE and MMSE were noted between two groups,The electrophysio logical findings suggested that there be cognitive dysfunction in some diabetic patients,and ERP might be a sensitive,objective and simple electrophysological method for detecting cognitive dysfunction.
