胃尔宁片治疗慢性萎缩性胃炎的临床及实验研究

Clinical and experimental study on chronic atrophic gastrits treated with Weierning tablet

为观察胃尔宁片对慢性萎缩性胃炎（ＣＡＧ）脾虚气滞证的疗效进行临床及实验研究。采用单官法设对照组，对照药为维酶素片，治疗组与对照组疗程均为８周，并在服药前后均作纤维胃镜及病理活检对照。结果表明，治疗组显效以上为７３．４％，总有效率为９７．５％，肠上皮化生消失率为３４． ５％，不典型增生消失率为３０． ６％，与对照组比较 Ｐ＜０． ０１有非常显著性差异。动物试验应用Ｗｉｓｔａｒ大鼠作ＣＡＧ模型试验及长期慢性毒性试验。结果表明：高剂量（１０ｇ／ｋｇ）组有轻度兴奋反应，中（５ｇ／ｋｇ）、低（１ｇ／ｋｇ）剂量组无毒副反应。动物ＣＡＧ模型试验表明，胃尔宁片除有显著的消炎、强壮、健脾作用外，还有促进萎缩腺体再生和修复之功效。对狗胃肠电活动影响，主要起抑制效应，有解痉止痛作用。提示：胃尔宁片对ＣＡＧ脾虎气滞证者有良好的治疗作用，能促进萎缩腺体再生和修复，并能使部分肠上皮化生及不典型增生消失或好转，这对防止ＣＡＧ恶性变有重要意义。

The patients with atrophic gastritis characterized by deficiency of spleen and stagnation of qi were divided into Weierning tablet group (WTG) and Weimeisu group (WG). The course of these patients were eight weeks and gastroscope,pathlogical biospy of were examinated before and after treatment. The results showed that in WTG, the remarkable effectual rate was 73. 4%,total effective rate was 97.5%,elimination rate of metaplasia and atypical hyperplasia of intestinal epithelium were respectively 34.5%, 3. 06%. Compared with WG there were significant different (P <0. 01). At same time .the wistar rats with CAG were respectively given 10g/kg,5g/ kg, 1g/kg Weierning tablet. The results showed that ① in 10g/kg dosage group rats appears slightly exciting reaction, but 5g/kg and ig/kg dosage group had not any toxic and side reaction; ② Weierning tablet had a better effects of antiinflammation,strengthening the spleen,and promoting the renovation and regeneration of the atrophic gland body. In addition,Weierning tablet had inhibited action for the dog gastrointestinal electrical move.