抗磷脂抗体与不孕及反复流产妇女的关系

The Relationship of Antiphospholipid Anti-bodies with Infertility and Recurrent Miscar-riage.

进行了抗磷脂抗体(APA)与不孕及反复流产妇女的关系研究。取原发性不孕症病人50例为研究组A;反复流产的患者63例为研究组B;已生育过健康子女的非孕其他妇科病患者50例为对照组。分别测定抗心磷脂抗体(ACL)和狼疮抗凝抗体(LA),结果:研究组A的APA阳性占22.0％(11/50),研究组B占23.81％(15/63),对照组占4.00％;研究组与对照组相比有显著差异(P<0.05,P<0.01);单纯ACL阳性仅在研究组B有意义(P<0.01);LA的阳性率在研究组A占18.00％,研究组B占14.29％,虽明显高于对照组的4.00％,但无统计差异(P>0.05;P>0.05)。本研究证实APA与反复流产发病有关,其存在可能是不孕的原因之一。发生机理考虑为APA对精子产生影响,造成受精失败,认为狼疮抗凝抗体(LA)可能与不孕症的关系更大。

The abjective of this study is to find the relationship of antiphospholipid antibodies (APA) with infertility and recurrent mis-carrage. Study group A consisted 50 patients of primary infertility; Study B 63 patients of recurrent miscarriage. Fifty normal fertile women were studied as a control group. Anticardiolipin antibodies (ACL) and lupus anticoagulate (LA) were determined. The results showed a positive APA in 22. 00% (11/50) and 23. 81% (15/63) of patients in study group A and B respectively. It was only 4. 0% (2/50) in the control group. There is a significant difference between the study groups and the control group (P<0. 05;P<0. 01). Positive ACL was found significant only between group B and the control. The ratio of positive LA were 18. 0% and 14. 29% in study group A and B respectively. The differences with the control group were not significant. The study confirmed that APA is related to the recurrent miscarriage. It may be also one of the reasons causing infertility. The mecha- nism could be due to the effect of APA on the fertilization of sperm. LA could be more important in relation to infertility.