超氧化物歧化酶对实验性糖尿病的预防及治疗作用观察

Effect of superoxide dismutase on the prevention and treatment of experimental diabetes

用国产牛／猪红细胞超氧化物歧化酶（ＳＯＤ）对糖尿病大鼠进行干预治疗，以期了解使用抗氧化酶能否影响糖尿病（ＤＭ）的进程。结果显示，与实验对照组比较，预防组和治疗组发病率由１００％降至４０％、７０％、７５％和８５％；死亡率由６０％分别降至１５％、２０％、２０％及２５％；葡萄糖耐量显著改善；胰腺组织脂质过气化物（ＬＰＯ）含量减少，ＳＯＤ活力升高，病理观察也支持上述结论。

The potential effect of native swine and bovine erythrocyte SOD on the intervention of al-loxan-induced diabetes was studied in rats.SOD was injected intravenously 30 min before alloxan and 2h、8h and 20h later.It was observed that diabetes induced was significantly attenuated.The survival rate of rats elevated notably.The glucose tolerance of these rats was obviously improved. Observation of B cells in islets under light microscope confirmed the results.Our results support the hypothesis that oxygen radicals mediated the B cell toxicity of alloxan.Injection of SOD in time has protective effect against alloxan-induced diabetes.