NIDDM患者微量白蛋白尿与冠心病的关系

The relationship between microalbuminuria and coronary heart disease in NIDDM

１０９例年龄≤６０岁的ＮＩＤＤＭ患者，其中４０例并有微量白蛋白尿或早期蛋白尿，６９例正常白蛋白尿，分析比较两组心血管疾病危险因素与心脏受损情况，结果发现微量白蛋白尿组与正常白蛋白尿组相比，缺血性心电图异常发生率较高（２５％比１５．９％），超声心动图左室舒张末期内径较大（４．８６±０．５４ｃｍ比４．６９±０．５５ｃｍ，Ｐ＜０．０５），表明微量白蛋白尿组有心脏受损较多的倾向，提示微量白蛋白尿是ＮＩＤＤＭ患者发生缺血性心脏病的危险信号。

The heart rate, blood pressure, electrocardiogram(ECG), ultrasonic-cardiogram(UCG), plasma glucose, serum insulin, triglyceride(TG), high density lipoprotein(HDL), cholestrol,glycosylated hemoglobin and urine albumin excretion rate(UAER) were examined in 109 NIDDM patients. Forty of them were found to have microalbuminuria or early proteinuria and 69 were normal with regard to microalbuminuria. The results showed that the patients with microalbuminuria had higher incidence of ischemic ECG abnormality (25%vs 15.9%)and larger left ventricular end-diastolic caliber than those with normal microalbuminuria (4.86±0.54 cm vs 4.69±0.55 cm,P<0.05).These data indicated NIDDM patients with microalbuminuria were apt to have the heart damage, and microalbuminuria might be a dangerous signal of ischemic heart disease in NIDDM.