胃癌及异型增生的形态定量诊断

A MORPHOMETRIC DIAGNOSIS OF GASTRIC CANCER AND EPITHELIAL DYSPLASIA OF THE STOMACH

本文应用西德LEITZ公司的ASM68K自动图象分析仪,对83例胃粘膜病变的P_1/D_1,P_2/D_2和ING初步进行了研究。测量结果表明:胃粘膜单纯肠化生、异型增生和分化型腺癌三组的P_1/D_1,P_2/D_2,ING值随病变异型程度的加重而递增,而且各组间皆有非常显著性差异(P<0.01)。因此,我们认为P_1/D_1,P_2/D_2和ING值可作为胃癌及异型增生的定量诊断和异型程度分级判定的客观形态检测指标。

The P1/D1, P2/D2 arid ING value of the gastric mucosal lesions in 83 cases with gastric carcinoma or peptic ulcer were studied with automatic image analyzer (model ASM 68K, LEITZ CO, West Germany). The results of this detection demonstrated that the P1/D1, P2/D2 and ING value in each guoup of simple intestinal metaplasia, dysplasia and differentiated adenocarcinoma increased depending on the degree of dysplasiaof the lesion, and the differences between these 3 groups were statistically significant (P<0.01). Therefore, the authors suggested that P1/D1, P2/D2 and ING value could be servedas objective, morphometric criteria for quantitative diagnosis and grading of gastric cancer and epithelial dysplasia of gastric mucosa.