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羟甲芬太尼对幼年大鼠学习和记忆的影响 被引量:2

Effects of Ohmefentanyl on learning and memory in infant rats
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摘要 本文用Spraque-Dawley大鼠为实验动物,从生后一日龄起每日皮下分别注射一次羟甲芬太尼(ohmefentanyl,OMF)(0.1,0.5,1.0,5μg/100gb.w),对照组注射等量的生理盐水。连续注射14天,观察16日龄幼鼠的吸乳迷津分辨学习(ADL)、30日龄幼鼠的Y迷津明暗分辨学习(BDL)行为与45日龄幼鼠不同脑区蛋白质含量的变化。结果如下:(1)各组剂量的OMF都能显著抑制幼鼠的ADL学习能力;(2)低、中等剂量(0.1,0.5,1.0μg/100gb.w)的OMF能显著抑制幼鼠的BDL学习能力;(3)各组剂量的OMF使海马的蛋白质含量显著降低。实验结果提示在生后脑发育过程中,阿片肽能影响幼鼠的学习行为,其原因可能与海马蛋白质含量变化有关。 Infant spraque-Dawlley rats were divided into several groups and received daily injection of saline,ohmefentanyl(0.1,0.5,1.0,5.oug/100gb,w) respectively from postnatal days 1-14. They were trained in the appetitive discrimination learning(ADL) at the age of 16 days ,then in the bright discrimination learning of Y-maze(BDl) at 30 days of age. On days 45, the content of brain protein of the rats was examined. The results were as follows: (1) four doses of ohmefentanyl significantly inhibited learning behavior in ADl.(2) Lower and middle doses significantly inhibited in BDl.(3) four doses can decreased the content of brain protein. Results suggest that the endogenous opioid system may influence some behavior during postnatal brain development of infant rats.
出处 《中国行为医学科学》 CAS CSCD 1996年第2期68-70,共3页 Chinese Journal of Behavioral Medical Science
关键词 学习 记忆 羟甲芬太尼 Ohmefentanyl infant Learning Memory
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