宫颈肿瘤ⅠB～ⅡA期预后相关因素(英文)

Prognostic factors and survival of stage ⅠB-ⅡA cervical cancer

Objective:This study investigated the prognostic significance of age at diagnosis, stage, tumor subtype, pelvic lymph node metastasis (PLNM), lymph-vascular space involvement (LVSI), presence or absence of deep cervical stromal invasion (DCSI) in stage ⅠB-ⅡA cervical cancer patients. It also investigated the inter-relationship among these factors. Methods: 152 patients treated with radical hysterectomy plus pelvic lymphadenectomy were followed up for a median of 49 months and were evaluated retrospectively. Results: The 5-year overall survival rate was 84.8%. The distribution of age at diagnosis is of bimodal shape, peaking at 42 and 68 years, respectively. Tumor subtype, PLNM, DCSI, and LVSI were found to be significant prognostic factors individually. After multivariate analysis, only tumor subtype and PLNM were found to be independent, significant prognostic factors for survival. The prognostic importance of LVSI appeared to be eclipsed by the presence of PLNM. DCSI was statistically related with FIGO stage, LVSI and PLNM. Conclusion: Tumor subtype and PLNM are the two most important independent prognostic factors for stages ⅠB-ⅡA cervical cancer. Some prognostic factors are inter-related and may reflect different facets of tumor progression.

ABSTRACT Objective：This study investigated the prognostic significance of age at diagnosis, stage, tumor subtype, pelvic lymph node metastasis （PLNM）, lymph-vascular space involvement （LVSI）, presence or absence of deep cervical stromal invasion （DCSI） in stage ⅠB- Ⅱ A cervical cancer patients. It also investigated the inter-relationship among these factors. Methods： 152 patients treated with radical hysterectomy plus pelvic lymphadeneetomy were followed up for a median of 49 months and were evaluated retrospectively. Results： The 5-year overall survival rate was 84.8%. The distribution of age at diagnosis is of bimodal shape, peaking at 42 and 68 years, respectively, Tumor subtype, PLNM, DCSI, and LVSI were found to be significant prognostic factors individually. After multivariate analysis, only tumor subtype and PLNM were found to be independent, significant prognostic factors for survival. The prognostic importance of LVSI appeared to be eclipsed by the presence of PLNM. DCSI was statistically related with FIGO stage, LVSI and PLNM. Conclusion： Tumor subtype and PLNM are the two most important independent prognostic factors for stages ⅠB- Ⅱ A cervical cancer. Some prognostic factors are inter-related and may reflect different facets of tumor progression. KEY WORDS Cervix neoplasms; Adenocarcinoma; Prognosis; Survival