期刊文献+

生长激素释放肽的结构和功能 被引量:1

下载PDF
导出
摘要 生长激素释放肽(growth hormone releasing peptide,Ghrelin,GHRP),是最近发现的可以促进GH分泌的肽激素,主要来源于胃,有28个氨基酸残基,其第三位氨基酸残基(一般是丝氨酸)被脂肪酸修饰,实验证明被修饰的N端是其活性核心部位。该文介绍ghrelin的主要结构和生物学功能。
作者 应牡英
出处 《生命的化学》 CAS CSCD 北大核心 2006年第1期30-33,共4页 Chemistry of Life
  • 相关文献

参考文献18

  • 1Matsumoto M et al, Biochem Biophys Res Commun, 2001, 287:142-146.
  • 2Anderson P et al. Microbiol Mol Biol Rev, 1997, 61(1): 33-46.
  • 3Kiahimoto M et al. Biochem Biophys Res Commun, 2003, 305:186-192.
  • 4Kanamoto N et al, Endocrinology, 2004, 145(9): 4144-4153.
  • 5Inui A, Nat Rev Neurosci, 2001, 2(8): 551-560.
  • 6Dixit VD et al. J Clin Invest, 2004, 114:57-66.
  • 7Qi X et al. Exp Biol Med(Maywood), 2003, 228(9): 1028-1032.
  • 8许志威,吴伟康.Ghrelin抗心力衰竭的作用及机制研究[J].国外医学(生理病理科学与临床分册),2005,25(3):241-243. 被引量:1
  • 9Casanueva FF. Trends Endocrind Metab, 1999, 10:30-38.
  • 10Baldanzi G et al. J Cell Biol, 2002, 159(6): 1029-1037.

二级参考文献18

  • 1Kojima M, Hosoda H, Nalazato M, et al. Ghrelin is a growth-hormone-releasing aeylated peptide fromstomaeh [J]. Nature, 1999,402(6762) :656-660.
  • 2van der L, Aart J, Matthias T, et al. Biological, physiological,pathophysiological and pharmacological aspects of ghrelin [J]. Endocr Rev, 2004.25(3):426-457.
  • 3Cassoni P, Papotti M,Ghe C, et al. Identification, characterization,and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines [J]. J Clin Endocrinol Metab , 2001,86(4) : 1738-1745.
  • 4Iglesiasa M J, Pineiroa R, Blanco M, et al. Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes[J]. Cardiovasc Res ,2004,62(3) :481-488.
  • 5Baldanzi G, Filigheddu N, Cutrapi S, et al. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT[J]. J Cell Biol,2002,159(6) : 1029-1037.
  • 6Benso A, Broglio F, Marafetti L, et al. Ghrelin and synthetic growth hormone secretagogues are cardioactive molecules with identities and differences[J]. Semin Vascu Med,2004 ,4(2) : 107-114.
  • 7Nagaya N, Uematsu M, Kojima M, et al. Elevated circulating level of ghrelin in cachexia associated with chronic heart failure : relationships between ghrelin and anabolic/catabolic factors [J]. Circulation, 2001,104(17) :2034-2038.
  • 8Nagaya N, Uematsu M, Kojima M, et al. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure [J]. Circulation,2001,104 (12) : 1430-1435.
  • 9Shimizu Y, Nagaya N, Teranishi Y, et al. Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats [J]. Biochem Biophys Res Commun, 2003,310 (3) : 1146-1152.
  • 10Frascarelli S, Ghelardoni S, Ronca-Testoni S, et al. Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart[J]. Basic Res Cardiol, 2003,98(6):401-405.

同被引文献30

  • 1Kojima M,Hosoda H,Date Y,et al.Ghrelin is a growth-hormone-releasing acylated peptide from stomach[J].Nature,1999,402:656-660.
  • 2Luo Xb,Inge D,Catherine T,et al.Evidence for the presence of motilin,ghrelin,and the motilin and ghrelin receptor in neurons of the myenteric plexus[J].Regulatory Peptides,2005,124:119-125.
  • 3Camerer E,Kataoka H,Kahn M,et al.Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells[J].J Biol Chem,2002,277(18):16 081-16 087.
  • 4Coughlin S R,Camerer E.PARticipation in inflammation[J].J Clin Invest,2003,111(1):25-27.
  • 5Qi X,Reed J,Englander E W,et al.Evidence that growth hormone exerts a feedback effect on stomach ghrelin production and secretion[J].Exp Biol Med (Maywood),2003,228 (9):1 028-1 032.
  • 6Dixit V D,Schaffer E M,Pyle R S,et al.Ghrelin inhibits leptin-and activation-induced proinflammatory cytokine expression by human monocytes and T cells[J].J Clin Invest,2004,114:57-66.
  • 7Nakazato M,Murakami N,Date Y,et al.A role for Ghrelin in the central regulation of feeding[J].Nature,2001,409:194-198.
  • 8Inui A.Ghrelin:an orexigenic and somatotrophic signal from the stomach[J].Nat Rev Neurosci,2001,2(8):551-560.
  • 9Fujino K,Inui A,Asakawa A,et al.Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats[J].J Physiol,2003,550:227-240.
  • 10Tack J,Depoortere I,Bisschops R,et al.Ghrelin-induced gastric phase Ⅲ activity is not accompanied by a plasma motilin peak[J].Gastroenterology,2004,126:A74.

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部