摘要
目的研究醛固酮合成酶(CYP11B2)基因-344T/C多态性及烟酒茶嗜好相互作用与急性脑梗死(ACI)易感性的关系。方法采用病例对照研究方法,调查研究对象的生活习惯,采用聚合酶链反应限制性内切酶长度多态性(PCR-RFLP)方法检测CYP11B2的基因型。结果病例组CYP11B2基因TC和CC基因型的频率显著高于对照组,分别为38.12%和9.97%;相对于TT基因型,暴露于TC和CC基因型人群的OR值分别为1.72和1.88。病例组C等位基因的频率也显著高于对照组,为29.03%;相对于T等位基因,C等位基因的OR值为1.57。此外研究还显示CYP11B2基因TC或CC基因型与吸烟相互作用可增加ACI的易感性,而该基因型与饮酒、饮茶无显著相互作用。结论当个体携带TC或CC基因型时,ACI的易感性增加,该两种基因型与吸烟相互作用,可增加ACI的易感性。
Objective To investigate the relationship between aldosterone synthase ( CYP11 B2) gene-344T/C polymorphism, dietary habits and the risk of acute cerebral infarction (ACI). Methods The dietary habits data were collected by case-control study. -344T/C polymorphism of CYP11 B2 gene was monitored by polymerize chain reactlon-restriction fragment length polymorphism (PCR-RFLP). Results The frequency of TC, CC in ACI cases were significantly higher than those in controls (38. 12%, 9. 97% ). The odds ratios (OR) for those exposed to TC and CC genotypes were 1.72 and 1.88, comparing with that to TT genotype. The frequency of C allele in ACI cases was 29. 03%, significantly higher than that of controls. The OR for those exposed to C allele was 1.57, comparing with that to T allele. In addition, TC or CC genetype interacted with smoking to increase the risk of ACI; No interaction was observed between TC, CC genetype and alcohol drinking or tea intake. Conclusions The CYP11B2-344 TC or cC genetype might increase the risk of ACI development and the genetype might also interact with smoking to increase the susceptibility of ACI.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2006年第1期7-9,共3页
Chinese Journal of Gerontology
关键词
醛固酮合成酶
脑梗死
基因
吸烟
饮酒
饮茶
Aldosterone synthase
Cerebral infarction
Gene
Smoking
Alcohol drinking
Tea drinking