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男性冠心病患者脂蛋白(a)与性激素和纤溶活性的关系

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摘要 目的探讨男性冠心病(CHD)患者脂蛋白(a)〔Lp(a)〕与性激素和纤溶活性的关系。方法分别用ELISA法对Lp(a),用放射免疫法对雌二醇和睾酮含量,用底物显色法对组织型纤溶酶原激活剂(tPA)及其抑制物(PAI)活性进行检测。结果男性CHD患者血浆睾酮浓度和tPA活性显著低于对照组,而Lp(a)浓度和PAI活性显著高于对照组,且男性CHD患者血浆Lp(a)水平与睾酮浓度、tPA活性显著负相关,与PAI活性显著正相关。结论血浆睾酮水平下降是男性CHD发生的主要原因。睾酮水平下降减弱了睾酮本身对动脉粥样硬化的抑制作用,同时通过引起Lp(a)水平升高而导致CHD的发生。
作者 闫智宏 马爱君 李付强 梁庆智
机构地区 河北北方学院生化教研室 张家口市第一医院心血管内科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2006年第1期21-22,共2页 Chinese Journal of Gerontology
关键词 脂蛋白(a) 睾酮 冠心病 纤溶酶原激活剂 纤溶酶原激活剂抑制物
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献8

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中国老年学杂志
2006年 第1期

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