抑郁症患者血清叶酸和维生素B12浓度研究

Study on serum folic acid and vitamin B12 levels of patients with depression

目的:探讨抑郁症患者血清叶酸和维生素B12浓度改变。方法:收集门诊患者76例,均符合国际疾病分类第10版抑郁症诊断标准,病程至少半年;健康对照组67名。测定血清叶酸和维生素B12浓度。结果:两组之间叶酸平均浓度和叶酸缺乏的发生差异均无显著性(P>0.05)。抑郁症组维生素B12平均浓度显著较低(P<0.05),维生素B12缺乏的发生率显著较高(P<0.01)。结论:抑郁症与维生素B12缺乏有关,与叶酸无关。

Objective：To explore the changes of serum folio acid and vitamin B12 levels in patients with depression. Method：76 outpatients who met the diagnosis of 10th edition of International Classification Disease for depression. Whose courses lasted at least six months. 67 healthy adults were served as controls. Serum folic acid and vitamin B12 levels were examined for all the subjects. Results：There was not statistically significant differences in mean serum folic acid levels and the occurence of low serum folic acid levels between two groups（ P 〉 0.05） .The mean serum vitamin B12 level was significantly lower （ P 〈 0.05）, and the occurence of low serum vitamin levels was significantly higher in the depression group（ P〈0.01 ）. Conclusion： Depression has some relationship with vitamin B12 deficiency, but no relationship with folic acid.