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大豆异黄酮对Aβ_(1-42)诱导的PC12细胞损伤的保护作用 被引量：2

Protection of Soybean Isoflavones to Aβ_(1-42) Induced Toxic on PC12 Cell
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摘要 目的:探讨大豆异黄酮提取物对β淀粉样蛋白片段(Aβ1-42)诱导的PC12细胞损伤的保护作用。方法:从大豆中提取并纯化出总异黄酮,通过PC12细胞株体外培养的方法,给予不同剂量的大豆异黄酮预处理,并用10μmol/L Aβ1-42诱导的细胞损伤,检测经处理后细胞MTT及PC12细胞形态的变化。结果:大豆异黄酮可显著降低Aβ1-42诱导的PC12细胞损伤,显著提高细胞的MTT值(P<0.05),并改善细胞的形态,与雌二醇组比较没有显著差异(P>0.05)。结论:大豆异黄酮对Aβ1-42诱导的PC12细胞具有保护作用。 Objective： To explore the effects of the soybean isoflalones to Aβ1-42 induced toxic on PC12 Cell. Methods： the cell culture PC12 were exposed to 10μmol/L Aβ1-42 for 24h pertreat with soybean isoflavones for 2hs. The morphololycal and survival of PC12 were observed by MTT. Results： The survival rate of PC 12 were decreased after treatment of soybean isoflavones and reshape the morphological of cell. Conclusion： Soybean isoflavone has protective effects on PC12 cell.
作者 赵宇红
机构地区 广东药学院
出处 《中药材》 CAS CSCD 北大核心 2006年第1期43-45,共3页 Journal of Chinese Medicinal Materials
关键词 PC12细胞 大豆异黄酮提取物 Β淀粉样蛋白 PC12 cell Soybean isoflavones Amyloid beta
分类号 R285.5 [医药卫生—中药学]
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参考文献9

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二级参考文献11

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共引文献32

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二级引证文献14

中药材
2006年 第1期

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