非霍奇金淋巴瘤侵犯骨髓及合并淋巴瘤细胞白血病的临床分析

The Clinical Analysis of Non-Hodgkin' s Lymphoma (NHL) with Bone Marrow Invasion and Lymphoma Cell Leukemia

目的:了解非霍奇金淋巴瘤骨髓侵犯的特征与病理类型、临床表现、治疗及预后的关系。方法:413 例经病理学诊断为非霍奇金淋巴瘤患者经骨髓穿刺检查后,对112例诊断为骨髓侵犯患者的骨髓病理形态学特征、骨髓侵犯程度与临床表现、分期,疗效以及生存时间的关系进行分析。结果:骨髓侵犯的发生率为27．12％,骨髓侵犯的形态学特征与原发肿瘤的一致;骨髓侵犯以B细胞淋巴瘤多见,多发生在晚期;骨髓侵犯程度与临床表现、疗效、预后明显相关,骨髓侵犯越重,临床症状越重,预后不良。结论:非霍奇金淋巴瘤骨髓侵犯的形态学特征与原发肿瘤细胞的形态一致,骨髓侵犯程度越重,临床出现各种相关症状重,化疗的缓解率低,疗效差,生存期明显缩短,预后不良,但仍有治愈的机会。

Objective： To investigate the relationships between the eharacteristic of bone marrow invasion, the pathologic type, clinical features, treatment and prognosis of non-Hodgkin＇s lymphoma. Methods： The study included 112 patients diagnosed as non-Hodgkin＇ s lymphoma with bone marrow invasion by pathology. Their morphological characteristics, degree of bone marrow invasion, pathologic type, clinical features staging, curative effect, survival time and their interrelationships were analyzed. Results： The incidence of bone marrow invasion was 27. 12%, the morphological characteristic was just as same as the primary tumor. Bone marrow invasion was common in B-cell lympoma, especially in advanced stags. The degree of invasion was correlated significantly with the clinical features, curative effect and prognosis. Conclusions： In non-Hodgkin＇ s lymphoma the morphological characteristic of bone marrow invasion is as same as the primary tumor. The more serious the bone marrow is invaded, the more serious the clinical symptoms is, the poorer the remission rate of chemotherapy is, the worse the curative effect is, the shorter the survival time is, the worse the prognosis is. But there is still the chance to cure.