摘要
糖代谢是能量代谢的核心组成部分,糖代谢异常与许多疾病,如糖尿病、缺血性心脑损伤和肿瘤等重大疾病有密切的关联。因此,通过对各种糖代谢通路进行有针对性的干预,有望开发出新型治疗药物。本文从糖尿病、缺血性心脑损伤、中风、肿瘤等4个方面,综述了近年来以糖代谢干预为基础的新药研究进展。
Aim：Glycometabolism makes up the core part of energy metabolism. Abnormalities in glycometabolism is tightly related with some serious diseases, such as type 2 diabetes, ischemic heart and brain diseases, and tumors. Hence it is hopeful to exploit new therapeutic drugs by pharmacological interference glycometabolism pathway. From 4 aspects as diabetes, ischemic heart and brain diseases, strokes and tumors, this paper reviews the research advances of drug development based on interference in glycometabolism.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2006年第1期1-8,共8页
Journal of China Pharmaceutical University
基金
教育部"2005年度新世纪优秀人才支持计划"资助项目
高等学校博士学科点专项科研基金资助项目(No.Y051018)
江苏省自然科学基金资助项目(No.BK2005101)~~
关键词
糖代谢干预
糖原代谢
糖异生
糖酵解
乳酸中毒
interference in glycometabolism
glycogen metabolism
gluconeogencsis
glycolysis
lactic acidosis
