壳聚糖-明胶海绵状伤口敷料的制备及性能研究

The Preparation and Performance of the Sponge of Chitosan-Gelatin

通过冷冻壳聚糖-明胶共混液诱导相分离的方法，可以制成多孔性、亲水性、透气性良好的海绵状伤口敷料。影响海绵体敷料结构形态及性能的因素主要有共混液中壳聚糖与明胶比例、共混液总浓度、粉末量和交联剂用量等。其用量最佳配比为：壳聚糖50％／明胶50％／总浓度2．2％～2．5％／粉末量1：1／交联剂用量1％。

By freezing chitosan gelatin complex induced phasic abruption, the porous and ventilative sponge of echitosan-gelatin was made. The factor that affects the structure and performance of sponge mostly comprises the proportion of chitosan and gelatin in admixture, overall consistence of mixed solution the dosage of powder the dosage of crosslinking reagent, etc, The best proportion of dosage was. chitosan 50%, and gelatin 50%, overall consistence of mixed solution 2. 2%-2. 5%, the dosage of powder 1：1, and the dosage of crosslinking reagent 1%.