TGF－α在子宫颈部肿瘤发生过程中的变化研究

Studies on Change of Transforming Growth Factor α in the Developmental Course of Cervical Cancer

用单克隆抗体免疫组化酶抗体ＡＢＣ法在正常子宫颈、子宫颈息肉、尖锐湿疣、ＣＩＮ原位癌、浸润癌等各种活检组织中检测转移生长因子（ＴＧＦ－α）的存在。结果发现，宫颈上皮内瘤（ＣＩＮ）Ⅰ～Ⅱ呈轻度阳性反应，ＣＩＮⅢ绝大部分为阴性，子宫颈鳞癌、腺癌病例出现中度至强阳性反应，提示了ＴＧＦ－α和子宫颈部肿瘤的发生。

The immunohistochemical enzyme antibody ABC method with monoclonal antibody was used to detect transforming growth factor α(TGF α) in the biopsy tissues of normal cervix, polyp of cervix, acuminatum condyloma, CIN, carcinoma in situ, and infiltrating cancer. Slight positive response in CIN Ⅰ￣Ⅱ, negetive response in most of CIN Ⅲ, moderate and strong positive response in cases of squamous cell carinoma of cervix and adenocarcinoma were found. There was a high correlation between TGF α and the development of cervical cancer. \ \