牛黄蛇胆川贝滴丸对COPD急性发作期的血气影响

Effect of niuhuang shedan chuanbei pill drops on blood gas in patients with obstructive pulmonary disease during acute attack

目的探讨牛黄蛇胆川贝滴丸对慢性阻塞性肺疾病(COPD)急性加重期时血气的影响。方法将72例住院患者随机分为治疗组及对照组(各36例),治疗组采用抗生素及二羟丙茶碱并加用牛黄蛇胆川贝滴丸每次口服10粒,每日3次。对照组除不加用牛黄蛇胆川贝滴丸外,其治疗方案及治疗方法同治疗组,1周为1个疗程。结果1个疗程结束后测定治疗前、后血气PaO2及PaCO2变化情况,治疗组治疗前PaO2(55.3±16.2)mm Hg,治疗后为(68.2±8.7)mmHg(1mm Hg=0.133kPa),而PaCO2治疗前、后分别为(56.6±5.8)mm Hg及(40.1±5.4)mm Hg。对照组治疗前、后PaO2分别为(57.3±10.1)mm Hg及(61.6±6.6)mm Hg,PaCO2为(53.6±5.5)mm Hg及(52.6±6.9)mm Hg。与治疗前及对照组比较P<0.05。治疗组未见明显副反应。结论治疗组1个疗程后血气结果明显改善。牛黄蛇胆川贝滴丸对于改善患者缺氧、缓解病情、缩短病程有明显的效果。

Objective To investigate the effect of nuihuang shedan chuanbei pill drops on blood gas in patients with obstructive pulmonary disease（COPD） during acute attack. Methods Seventy COPD patients were assigned to the test group （36 cases） and the control group（36 cases）. Patients in the control group were only given the goutine treatment（ antibiotics and diprophynine） ,while patients in the test group were given niuhuang shedan chuanbei pill drops（ l0 pills each time,3 times per day）besides the routine treatment. The course of treatment was 1 week for both groups. Results After 1 treatment course, the level of PaCO2 were significantly decreased from （55.3 ± 16.2） mm Hg to （68.2 ± 8.7 ）mm Hg and the PaO2 were significantly raised from （56.6± 5.8 ）mm Hg to （40.1 ± 5.4） mm Hg after treatment in the test group （ P 〈 0.05 ）. While in the control group,PaO2 raised only from （57.3 ± 10. 1 ）mm Hg to （61.6±6.6）mm Hg, PaCO2 decreased from （53.6 ± 5.5 ）mm Hg to （52.6± 6.9） mm Hg （ P 〉 0.05 ）. The level of PaO2 were significantly higher and the PaCO2 significantly lower in the test group than that in the control group after treatment（ P 〈 0.05 ）. Conclusion For COPD patients, adding niuhuang shedan chuanbei pill drops makes obvious therapeutic effects,it is helpful to improve the blood gas indexes ,relieve the state of illness and shorten the disease duration.