口服β－羧乙基倍半锗氧化物后锗在24名中国人体内的药物动力学

Pharmacokinetics of germanium after po β carboxyethylgermanium sesquioxide in 24 Chinese volunteers

口服β羧乙基倍半锗氧化物后锗在２４名中国人体内的药物动力学龙启才，曾桂雄，赵香兰（中山医科大学临床药理教研室，广州５１００８９，中国）关键词锗；β羧乙基倍半锗氧化物；药物动力学；原子吸收分光光度测定法目的：比较口服不同剂量β羧乙基倍半锗氧化物（...

IM: To compare the pharmacokinetics after po different doses of β carboxyethylgermanium sesquioxide (Ge 132). METHODS: An atomic absorption spectrophotometric system was used to measure germanium concentrations in plasma and urine samples after po Ge 132 1 (low dose, LD), 2 5 (medium dose, MD), and 4 (high dose, HD) g·m -2 in 24 healthy volunteers (one dose per 8 subjects). RESULTS: T 12α (LD, 1 2±0 7 h; MD, 1 1±0 6 h; HD, 1 2±0 5 h), T 12β (LD, 5 2±1 2 h; MD, 5 8±2 5 h; HD, 5 5±1 4 h) and Cl / F (LD, 33±12 L·h -1 ; MD, 35±10 L·h -1 ; HD, 33±11 L·h -1 ) were not dose related. T max was between 0 75 h and 2 h. C max (LD, 5 3±2 2 mg·L -1 ; MD, 13±5 mg·L -1 ; HD 18±8 mg·L -1 , HD) and AUC (LD, 31±13 mg·h·L -1 ; MD, 60±16 mg·h·L -1 ; HD, 79±42 mg·h·L -1 ) were positive correlation to the dose of Ge 132. Urine eliminated germanium within 24 h accounted for 11±3 % of LD, 9±3 % of MD, and 6±5 % of HD (calculated from Ge/ F ) and showed a negative correlation to the dose. CONCLUSION: 1) Intracorporal process of Ge after po Ge 132 coincided with the first order absorption and elimination with two compartment kinetic model; 2) The amount of germanium eliminated in urine was below 11 %.