110株粪肠球菌的分布及耐药性分析

Analysis on distribution and drug resistance of 100 strains of E. faecalis

目的探讨100株粪肠球菌的分布及对10种抗生素的耐药情况。方法对临床分离到的100株粪肠球菌采用Kirby-Bauer纸片琼脂扩散法对10种抗生素的耐药情况进行分析。结果粪肠球菌主要分布在痰中55例,其次是尿液25例,大便16例,胸腹水3例,创口分泌物3例,其它2例。且对大多数常用抗生素耐药率都在50%以上,只有万古霉素、呋喃妥因、氯霉素等的耐药率较低,并发现4株耐万古霉素的粪肠球菌。结论临床标本中分离出的粪肠球菌应根据药敏试验结果合理地选用抗生素,为临床用药提供依据;且注意万古霉素的使用,防止该类药物耐药率的升高。

Objective To investigate the distribution and drug resistance against 10 antibiotics of 100 strains of Enterococcus faecalis. Methods To analyze the status of drug resistance of 100 streins of E. faecalis to 10 antibiotics with the way of Kirby-Bauer. Results E. faecalis distributed in spit （55）, then in urine （25）, next in feces （16）, in pleural fluid （3） , in wound excretion （3）, and in others （2）. The rates of drug resistance of E. faecalis to the most of the antibiotics often used were above 50% except vancomycin,nitrofurantion and chloromycetin. And 4 strains of E. faecalis resisitant to vancomycin were found. Conclusion Antibiotics should be selected resonably to E. faecalis isolated from the clinical specimen according to the result of drug resistance. Further more,use of vancomycin must be payed attention to prevent the increasing rate of drug resistance.