非酒精性脂肪肝患者血清瘦素水平检测的临床意义

The clinical significance of serum leptin levels in patients with nonalcoholic fatty liver

研究非酒精性脂肪肝患者血清瘦素水平检测的临床意义。选择门诊或住院患者非酒精性脂肪肝30例,正常对照30例,采用放射免疫法检测血清瘦素及胰岛素水平。结果发现,脂肪肝患者血清瘦素(23.7±13.1)μg/ml,胰岛素水平、(16.7±4.9)μg/ml显著高于正常对照组(4.7±3.2)μg/ml及(9.7±2.6)μg/ml,P<0.001。无论脂肪肝组还是正常对照组,血清瘦素水平升高存在性别差异,女性明显高于男性。脂肪肝患者存在瘦素抵抗和胰岛素抵抗,早期检测血清瘦素水平,为早期干预治疗脂肪肝提供了可能的途径。

To study the clinical significance of serum leptin levels in patients with nonalcoholic fatty liver. The serum leptin, insulin levels in 30 patients with nonalcoholic fatty liver. The serum leptin, insulin levels in 30 patients with nonalcoholic fatty liver and 30 normal controls were determined by means of radioimmnuoassay. We found that the serum leptin, insulin levels in 30 patients with nonalcoholic fatty liver （23.7 ± 13.1μg/ml, 16.7 ± 4.9μg/ml） were higher than those of controls （4.7 ± 3.2μg/ml, 9.7 ± 2.6μg/ml）, P 〈 0.001. The serum leptin levels in women patient were higher than those in man patients in the two groups. Leptin resistance and insulin resistance exist in the patients with nonalcoholic fatty liver. Early detection of serum leptin levels provide a possible way for early intervention of nonalcoholic fatty liver.