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南瓜胰蛋白酶抑制剂 被引量：2

Cucurbita maxima trypsin inhibitor
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摘要 南瓜胰蛋白酶抑制剂(CMTI)具有独特的结构特点和抑制机制。此文对丝氨酸蛋白酶抑制剂的分类和CMTI的分子结构特征、酶学特性以及生理功能等方面的研究进展做一介绍。
作者 徐扬 王凤山
机构地区 山东大学药学院生化与生物技术药物研究所
出处 《中国生化药物杂志》 CAS CSCD 2006年第1期49-51,共3页 Chinese Journal of Biochemical Pharmaceutics
关键词 南瓜胰蛋白酶抑制剂 丝氨酸蛋白酶抑制剂
分类号 Q74 [生物学—分子生物学]
  • 相关文献

参考文献16

  • 1van Gent D,Sharp P,Morgan K,et al.Serpins:structure,function and molecular evolution[J].Int J Biochem Cell Biol,2003,35(11):1536-1547.
  • 2Krowarsch D,Cierpicki T,Jelen F,et al.Canonical protein inhibitors of serine proteases[J].Cell Mol Life Sci,2003,60(11):2427-2444.
  • 3张宁,王凤山.胰蛋白酶抑制剂研究概况[J].中国生化药物杂志,2004,25(2):115-117. 被引量：14
  • 4Bode W,Huber R.Structural basis of the endoproteinase-protein inhibitor interaction[J].Biochim Biophys Acta,2000,1477(1-2):241-252.
  • 5Mans BJ,Louw AI,Neitz AW.Amino acid sequence and structure modeling of savignin,a thrombin inhibitor from the tick,Ornithodoros savignyi[J].Insect Biochem Mol Biol,2002,32(7):821-828.
  • 6Silverman GA,Lomas DA.Serpin identification,production,and characterization[J].Methods,2004,32(2):71-72.
  • 7Dafforn TR,Pike RN,BottomLey SP.Physical characterization of serpin conformations[J].Methods,2004,32(2):150-158.
  • 8Janciauskiene S.Conformational properties of serine proteinase inhibitors(serpins)confer multiple pathophysiological roles[J].Biochim Biophys Acta,2001,1535(3):221-235.
  • 9Kazmierczak K,Zablotna E,Jaskiewicz A,et al.Selection of low-molecular-mass trypsin and chymotrypsin inhibitors based on the binding loop of CMTI-Ⅲ using combinatorial chemistry methods[J].Biochem Biophys Res Commun,2003,310(3):811-815.
  • 10Chakraborty S,Haldar U,Bera AK,et al.Recognition and stabilization of a unique CPRI-structural motif in cucurbitaceae family trypsin inhibitor peptides:molecular dynamics based homology modeling using the X-ray structure of MCTI-II[J].J Biomol Struct Dyn,2001,18(4):569-577.

二级参考文献15

  • 1Haruta M, Major IT, Christopher ME, et al. A Kunitz trypsin inhibitor gene family from trembling aspen( Populus tremuloides Michx. ): cloning functional expression, and induction by wounding and herbivory[ J].Plant Mol Biol,2001,46(3) :347-359.
  • 2Mandal S, Kundu P, Roy B. Precursor of the inactive 2S seed storage protein from the Indian mustard Brassicajuncea is a novel trypsin inhibitor[J]. J Biol Chem,2002,277(40) :37161-37168.
  • 3Sant' Anna Azzolini S, Sasaki SD, Torquato R J, et al. Rhipicephalus sanguineus trypsin inhibitors present in the tick larvae: isolation, characterization, and partial primary structure deternminaton [ J ]. Arch Biochem Biophys,2003,417(2): 176-182.
  • 4Nagle GT, de Jong-Brink M, Painter SD, et al. Structure, localization and potential role of a novel molluscan trypsin inhibitor in Lymnaea[J]. Eur J Biochem,2001,268:1213-1221.
  • 5Kishimura H, Saeki H, Hayashi K. Isolation and characteristics of trypsin inhibitor from the hepatopancreas of a squid( Todarodes pacificus ) [ J ]. Comp Biochem Physiol, 2001, part B: 117-123.
  • 6Jung-Ho C, Pyo-Jam P, Se-Kuon K. Purification and characterization of a trypsin inhibitor from the egg of Skipjack tuna katsuwonus pelamis[J]. Fish Sci,2002,68: 1367-1373.
  • 7Paiva PM, Souza AF, Oliva ML, et al. Isolation of trypsin inhibitor from Echinodorus paniculatus seeds by affinity chromatography on immobilized Cratylia mollis isoleetins[ J ]. Bioresour Technol, 2003,88: 75-79.
  • 8Felizmenio-Quimio ME, Daly NL, Craik DJ. Circular proteins in plants:solution structure of a novel macrocyclic trypsin inhibitor from Momordica co1chinchinensis [ J ]. J Biol Chem, 2001, 276 ( 25 ): 22875-22882.
  • 9Marx UC,Korsinczky ML,Schirra HJ, et al. Enzymatic cyclization of apotent bowman-birk protease inhibitor, sunflower trypsin inhibitor-1,and solution structure of an acyclic precursor peptide [J]. J Biol Chem,2003,278(24) :21782-21789.
  • 10Chakraborty S, Haldar U,Bera AK, et al. Recognition and stabilization of a unique CPRI-structural motif in cucurbitaceae family trypsin inhibitor peptides: molecular dynamics based homology modeling using the Xray structure of MCTI-Ⅱ [J]. J Biomol Struct Dyn,2001,18(4):567-577.

共引文献13

同被引文献23

  • 1Rui-FengQI,Zhan-WuSONG,Cheng-WuCHI.Structural Features and Molecular Evolution of Bowman-Birk Protease Inhibitors and Their Potential Application[J].Acta Biochimica et Biophysica Sinica,2005,37(5):283-292. 被引量：16
  • 2曾仲奎,谢文胜,鲍锦库,周红.水稻巯基蛋白酶抑制剂的纯化及其性质研究[J].生物化学杂志,1996,12(6):703-708. 被引量：11
  • 3McBride C M, Renhowe P A, Gesner T G, et al. 3-Benzimidazol-2-yl- 1H-indazoles as potent c-ABL inhibitors [J]. Bioorg Med Chem Lett, 2006,16(14) :3789-3792.
  • 4Sparks R B, Polam P, Zhu W, et al. Benzothiazole benzimidazole ( S)- isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors [ J ]. Bioorg Med Chem Lett, 2007,17 (3) : 736-740.
  • 5Lavergne O, Fernandes A C, Brehu L, et al. Synthesis and biological evaluation of novel heterocyclic quinines as inhibitors of the dual specificity protein phosphatase CDC25 C [ J ]. Bioorg Med Chem Lett, 2006,16 (1) :171-175.
  • 6Hirashima S, Suzuki T, Ishida T, et al. Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NSSB RNA-dependent RNA polymerase inhibitors:Structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109 [ J ]. J Med Chem, 2006,49 ( 15 ) : 4721-4736.
  • 7Beaulieu P L, Gillard J, Bykowski D, et al. Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase:From benzimidazole to indole scaffolds [ J]. Bioorg Med Chem Lett, 2006,16(19) :4987-4993.
  • 8White A W, Curtin N J, Eastman B W, et al. Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors[J]. Bioorg Med Chem Lett, 2004,14(10) :2433-2437.
  • 9Franke L, Byvatov E, Werz O, et al. Extraction and visualization of potential pharmacophore points using support vector machines:Application to ligand-based virtual screening for COX-2 inhibitors[ J]. J Med Chem, 2005,48 (22) : 6997-7004.
  • 10Paramashivappa R, Kumar P P, Rao P V S, et al. Design, synthesis and biological evaluation of benzimidazole/benzothiazole and benzoxazole derivatives as cyclooxygenase inhibitors [ J ]. Bioorg Med Chem Lett, 2003,13(4) :657-660.

引证文献2

二级引证文献28

中国生化药物杂志
2006年 第1期

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